Application of charged single isomer derivatives of cyclodextrins in capillary electrophoresis for chiral analysis

被引：75

作者：

Cucinotta, Vincenzo ^{[1
]}

Contino, Annalinda ^{[1
]}

Giuffrida, Alessandro ^{[1
]}

Maccarrone, Giuseppe ^{[1
]}

Messina, Marianna ^{[1
]}

机构：

[1] Univ Catania, Dept Chem Sci, I-95125 Catania, Italy

来源：

JOURNAL OF CHROMATOGRAPHY A | 2010年 / 1217卷 / 07期

关键词：

Capillary electrophoresis; Cyclodextrins; Chiral separation; Ligand exchange capillary electrophoresis; SULFATED BETA-CYCLODEXTRIN; DANSYL-AMINO-ACIDS; ENANTIOMERIC SEPARATION; GAMMA-CYCLODEXTRIN; RESOLVING AGENTS; LIGAND-EXCHANGE; ZONE-ELECTROPHORESIS; BASIC COMPOUNDS; ELECTROKINETIC CHROMATOGRAPHY; BACKGROUND ELECTROLYTES;

D O I：

10.1016/j.chroma.2009.11.094

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The review focuses on the role of ionic or ionisable single isomer derivatives (SIDs) of cyclodextrins on the separation of chiral analytes in capillary electrophoresis (CE), covering the period since the year 2000. The advantages of using pure compounds are discussed, as well as the ways to optimise the separations in the context of a rational approach to these techniques. Specific attention is paid to the modulation of the selector-analyte interaction. The advantage due to a detailed knowledge of equilibria occurring in solution during the CE run is underlined, particularly in the case of the presence of metal complexes, as occurs in chiral ligand exchange capillary electrophoresis (CLECE). (c) 2009 Elsevier B.V. All rights reserved.

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页码：953 / 967

页数：15

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