Effects of tea polyphenols on signal transduction pathways related to cancer chemoprevention

被引:127
作者
Hou, Z [1 ]
Lambert, JD [1 ]
Chin, KV [1 ]
Yang, CS [1 ]
机构
[1] Rutgers State Univ, Ernest Mario Sch Pharm, Dept Biol Chem, Susan Lehman Cullman Lab Canc Res, Piscataway, NJ 08854 USA
关键词
tea polyphenol; EGCG; theaflavins; signal transduction; cancer prevention;
D O I
10.1016/j.mrfmmm.2004.06.040
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The inhibition of carcinogenesis by tea and tea polyphenols has been demonstrated in different animal models by many investigators. The mechanisms of this inhibitory activity have also been investigated extensively, mostly in cell culture systems, but no clear conclusion can be reached concerning the cancer preventive mechanisms in vivo. In this article, we reviewed the possible mechanisms, which include the inhibition of specific protein kinase activities, blocking receptor-mediated functions, and inhibition of proteases. These events may lead to cell cycle regulation, growth inhibition, enhanced apoptosis, inhibition of angiogenesis, and inhibition of invasion and metastases. The possible complications of translating results obtained in cell culture studies to animals and humans are discussed. It is likely that multiple signal transduction pathways are involved in the inhibition of carcinogenesis by tea constituents. The relative importance of these pathways needs to be determined in vivo. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码:3 / 19
页数:17
相关论文
共 90 条
[41]   Mechanisms of cancer prevention by tea constituents [J].
Lambert, JD ;
Yang, CS .
JOURNAL OF NUTRITION, 2003, 133 (10) :3262S-3267S
[42]  
Leone M, 2003, CANCER RES, V63, P8118
[43]  
Liang YC, 1999, J CELL BIOCHEM, V75, P1
[44]   Suppression of extracellular signals and cell proliferation by the black tea polyphenol, theaflavin-3,3′-digallate [J].
Liang, YC ;
Chen, YC ;
Lin, YL ;
Lin-Shiau, SY ;
Ho, CT ;
Lin, JK .
CARCINOGENESIS, 1999, 20 (04) :733-736
[45]  
Liang YC, 1997, J CELL BIOCHEM, V67, P55, DOI 10.1002/(SICI)1097-4644(19971001)67:1<55::AID-JCB6>3.0.CO
[46]  
2-V
[47]   Inhibition of lung carcinogenesis and effects on angiogenesis and apoptosis in A/J mice by oral administration of green tea [J].
Liao, J ;
Yang, GY ;
Park, ES ;
Meng, XF ;
Sun, YH ;
Jia, DX ;
Seril, DN ;
Yang, CS .
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 2004, 48 (01) :44-53
[48]   Growth factor-dependent induction of p21CIP1 by the green tea by polyphenol, epigallocatechin gallate [J].
Liberto, M ;
Cobrinik, D .
CANCER LETTERS, 2000, 154 (02) :151-161
[49]   Cancer chemoprevention by tea polyphenols through mitotic signal transduction blockade [J].
Lin, JK ;
Liang, YC ;
Lin-Shiau, SY .
BIOCHEMICAL PHARMACOLOGY, 1999, 58 (06) :911-915
[50]   Inhibition of melanoma growth and metastasis by combination with (-)-epigallocatechin-3-gallate and dacarbazine in mice [J].
Liu, JD ;
Chen, SH ;
Lin, CL ;
Tsai, SH ;
Liang, YC .
JOURNAL OF CELLULAR BIOCHEMISTRY, 2001, 83 (04) :631-642