LAYERED DOUBLE HYDROXIDES: INORGANIC NANOPARTICLES FOR STORAGE AND RELEASE OF SPECIES OF BIOLOGICAL AND THERAPEUTIC INTEREST

被引：47

作者：

Cunha, Vanessa R. R. ^{[1
]}

Ferreira, Ana Maria da C. ^{[1
]}

Constantino, Vera R. L. ^{[1
]}

Tronto, Jairo ^{[2
]}

Valim, Joao B. ^{[3
]}

机构：

[1] Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, BR-05513970 Sao Paulo, Brazil

[2] Univ Fed Vicosa, BR-38810000 Rio Paranaiba, MG, Brazil

[3] Univ Sao Paulo, Dept Quim, Fac Filosofia Ciencias & Letras Ribeirao Preto, BR-14040901 Ribeirao Preto, SP, Brazil

来源：

QUIMICA NOVA | 2010年 / 33卷 / 01期

关键词：

layered double hydroxides; inorganic carriers; drug release; IN-VITRO RELEASE; DRUG-DELIVERY SYSTEM; ANIONIC CLAYS; COMPUTER-SIMULATION; MULTIFUNCTIONAL NANOPARTICLES; INTERCALATION COMPOUNDS; SUSTAINED-RELEASE; HYBRID MATERIALS; LDH NANOHYBRID; AMINO-ACIDS;

D O I：

10.1590/S0100-40422010000100029

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

LAYERED DOUBLE HYDROXIDES: INORGANIC NANOPARTICLES FOR STORAGE AND RELEASE OF SPECIES OF BIOLOGICAL AND THERAPEUTIC INTEREST. Studies about the inorganic nanoparticles applying for non-viral release of biological and therapeutic species have been intensified nowadays. This work reviews the preparation strategies and application of layered double hydroxides (LDH) as carriers for storing, carrying and control delivery of intercalated species as drugs and DNA for gene therapy. LDH show low toxicity, biocompatibility, high anion exchange capacity, surface sites for functionalization, and a suitable equilibrium between chemical stability and biodegradability. LDH can increase the intercalated species stability and promote its sub-cellular uptake for biomedical purposes. Concerning the healthy field, LDH have been evaluated for clinical diagnosis as a biosensor component.

引用

页码：159 / 171

页数：13

共 132 条

[1]

Aisawa S, 2008, J NANOSCI NANOTECHNO, V8, P428, DOI 10.1166/jnn.2008.020

[2] Effect of hydrotalcite-like compounds on the aqueous solubility of some poorly water-soluble drugs [J].

Ambrogi, V ;

Fardella, G ;

Grandolini, G ;

Nocchetti, M ;

Perioli, L .

JOURNAL OF PHARMACEUTICAL SCIENCES, 2003, 92 (07) :1407-1418

[3] Intercalation compounds of hydrotalcite-like anionic clays with antiinflammatory agents - I. Intercalation and in vitro release of ibuprofen [J].

Ambrogi, V ;

Fardella, G ;

Grandolini, G ;

Perioli, L .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2001, 220 (1-2) :23-32

[4] Use of calcined Mg-Al-hydrotalcite to enhance the stability of celecoxib in the amorphous form [J].

Ambrogi, Valeria ;

Perioli, Luana ;

Marmottini, Fabio ;

Rossi, Carlo .

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2007, 66 (02) :253-259

[5]

[Anonymous], 2003, CHIN J DIG DIS

[6] Electrodes coated by hydrotalcite-like clays. Effect of the metals and the intercalated anions on ion accumulation and retention capability [J].

Ballarin, B ;

Gazzano, M ;

Seeber, R ;

Tonelli, D ;

Vaccari, A .

JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 1998, 445 (1-2) :27-37

[7] Synthesis and characterization of magnesium-aluminum layered double hydroxides containing (tetrasulfonated porphyrin)cobalt [J].

Barbosa, CAS ;

Ferreira, AMDC ;

Constantino, VRL .

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, 2005, (08) :1577-1584

[8] Urea biosensor based on Zn3Al-urease layered double hydroxides nanohybrid coated on insulated silicon structures [J].

Barhoumi, H ;

Maaref, A ;

Rammah, A ;

Martelet, C ;

Jaffrezic, N ;

Mousty, C ;

Vial, S ;

Forano, C .

MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS, 2006, 26 (2-3) :328-333

[9] Synthesis of organo-mineral nanohybrid material: indole-2-carboxylate in the lamella of Zn-Al-layered double hydroxide [J].

bin Hussein, MZ ;

Long, CW .

MATERIALS CHEMISTRY AND PHYSICS, 2004, 85 (2-3) :427-431

[10] Controlled release of a plant growth regulator, α-naphthaleneacetate from the lamella of Zn-Al-layered double hydroxide nanocomposite [J].

bin Hussein, MZ ;

Zainal, Z ;

Yahaya, AH ;

Foo, DWV .

JOURNAL OF CONTROLLED RELEASE, 2002, 82 (2-3) :417-427

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