Effects of different frequencies of repetitive transcranial magnetic stimulation in stroke patients with non-fluent aphasia: a randomised, sham-controlled study

被引：96

作者：

Hu, Xue-yan ^{[1
,2
]}

Zhang, Tong ^{[1
,2
]}

Rajah, Gary B. ^{[3
]}

Stone, Christopher ^{[3
]}

Liu, Li-xu ^{[1
,2
]}

He, Jing-jie ^{[1
,2
]}

Shan, Lei ^{[1
,2
]}

Yang, Ling-yu ^{[1
,2
]}

Liu, Ping ^{[1
,2
]}

Gao, Fei ^{[1
,2
]}

Yang, Yu-qi ^{[1
,2
]}

Wu, Xiao-li ^{[1
,2
]}

Ye, Chang-qing ^{[1
,2
]}

Chen, Yu-dong ^{[1
,2
]}

机构：

[1] China Rehabil Res Ctr, Dept Neurorehabil, Beijing, Peoples R China

[2] Capital Med Univ, Sch Rehabil Med, Beijing, Peoples R China

[3] Wayne State Univ, Sch Med, Dept Neurosurg, Detroit, MI USA

来源：

NEUROLOGICAL RESEARCH | 2018年 / 40卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Stroke; repetitive transcranial magnetic stimulation; aphasia; rehabilitation; NONINVASIVE BRAIN-STIMULATION; ISCHEMIC-STROKE; GLOBAL APHASIA; MOTOR CORTEX; POSTSTROKE; LANGUAGE; RECOVERY; THERAPY; SPEECH; IMPROVEMENT;

D O I：

10.1080/01616412.2018.1453980

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Objective: The purpose of this study was to compare the efficacy of repetitive transcranial magnetic stimulation (rTMS) applied at different frequencies to the contra-lesional hemisphere, to optimize the treatment of post-stroke non-fluent aphasia. Method: Patients with post-stroke non-fluent aphasia were divided randomly into four groups: a high-frequency rTMS (HF-rTMS) group (10 Hz), a low-frequency rTMS (LF-rTMS) group (1 Hz), a sham stimulation group, and a control group. All groups received the standard treatment (consisting of drug therapy, conventional physical exercises, and speech training); in the HF-rTIVIS and LF-rTMS, this was supplemented with magnetic stimulation that targeted the mirror area within the right hemispheric Broca's area. Patients' language ability was assessed prior to, immediately after, and at 2 months post-treatment by the Chinese version of the Western Aphasia Battery (WAB). Results: When measured immediately post-treatment, as well as at 2 months post-treatment, the LF-rTMS group exhibited a more marked improvement than the HF-rTMS group in spontaneous speech, auditory comprehension, and aphasia quotients (AQ). Compared to the control group, the HF-rTMS cohort exhibited significant improvement at 2-months post-treatment in repetition and AQ. Conclusions: LF-rTMS and HF-rTMS are both beneficial to the recovery of linguistic function in patients with post-stroke non-fluent aphasia. LF-rTMS produced immediate benefits that persisted long-term, while HF-rTMS only produced long-term benefits. In addition, the benefits produced with LF-rTMS were more marked than those produced by HF-rTMS.

引用

页码：459 / 465

页数：7

共 46 条

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Effectiveness of Low-Frequency rTMS and Intensive Speech Therapy in Poststroke Patients with Aphasia: A Pilot Study Based on Evaluation by fMRI in Relation to Type of Aphasia [J].