25-Hydroxyvitamin D levels and cognitive performance and decline in elderly men

被引：191

作者：

Slinin, Y. ^{[1
,3
]}

Paudel, M. L. ^{[4
]}

Taylor, B. C. ^{[1
,3
,4
]}

Fink, H. A. ^{[1
,2
,3
,4
]}

Ishani, A. ^{[1
,3
]}

Canales, M. T. ^{[5
,6
]}

Yaffe, K. ^{[7
,8
,9
,10
]}

Barrett-Connor, E. ^{[11
]}

Orwoll, E. S. ^{[12
]}

Shikany, J. M. ^{[14
]}

LeBlanc, E. S. ^{[13
]}

Cauley, J. A. ^{[15
]}

Ensrud, K. E. ^{[1
,3
,4
]}

机构：

[1] VA Med Ctr, Ctr Chron Dis Outcomes Res, Minneapolis, MN USA

[2] VA Med Ctr, Geriatr Res Educ & Clin Ctr, Minneapolis, MN USA

[3] Univ Minnesota, Dept Med, Minneapolis, MN 55455 USA

[4] Univ Minnesota, Div Epidemiol & Community Hlth, Minneapolis, MN USA

[5] Univ Florida, Dept Med, Gainesville, FL USA

[6] Malcolm Randal VA Med Ctr, Dept Med, Gainesville, FL USA

[7] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA

[8] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA

[9] Univ Calif San Francisco, Dept Epidemiol, San Francisco, CA 94143 USA

[10] VA Med Ctr, Dept Psychiat, San Francisco, CA USA

[11] Univ Calif San Diego, Dept Family & Prevent Med, Div Epidemiol, La Jolla, CA 92093 USA

[12] Oregon Hlth & Sci Univ, Bone & Mineral Unit, Portland, OR 97201 USA

[13] Oregon Hlth & Sci Univ, Dept Med, Portland, OR 97201 USA

[14] Univ Alabama Birmingham, Div Prevent Med, Birmingham, AL USA

[15] Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA 15260 USA

来源：

NEUROLOGY | 2010年 / 74卷 / 01期

关键词：

VITAMIN-D DEFICIENCY; 1,25-DIHYDROXYVITAMIN D-3; OSTEOPOROTIC FRACTURES; BRAIN-DEVELOPMENT; D-RECEPTOR; HEALTH; ASSOCIATION; HORMONE; DISEASE; RISK;

D O I：

10.1212/WNL.0b013e3181c7197b

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: To test the hypothesis that lower 25-hydroxyvitamin D [25(OH) D] levels are associated with a greater likelihood of cognitive impairment and risk of cognitive decline. Methods: We measured 25(OH) D and assessed cognitive function using the Modified Mini-Mental State Examination (3MS) and Trail Making Test Part B (Trails B) in a cohort of 1,604 men enrolled in the Osteoporotic Fractures in Men Study and followed them for an average of 4.6 years for changes in cognitive function. Results: In a model adjusted for age, season, and site, men with lower 25(OH) D levels seemed to have a higher odds of cognitive impairment, but the test for trend did not reach significance (impairment by 3MS: odds ratio [OR] 1.84, 95% confidence interval [CI] 0.81-4.19 for quartile [Q] 1; 1.41, 0.61-3.28 for Q2; and 1.18, 0.50-2.81 for Q3, compared with Q4 [referent group; p trend = 0.12]; and impairment by Trails B: OR 1.66, 95% CI 0.98-2.82 for Q1; 0.96, 0.54-1.69 for Q2; and 1.30, 0.76-2.22 for Q3, compared with Q4 [p trend = 0.12]). Adjustment for age and education further attenuated the relationships. There was a trend for an independent association between lower 25(OH) D levels and odds of cognitive decline by 3MS performance (multivariable OR 1.41, 95% CI 0.89-2.23 for Q1; 1.28, 0.84-1.95 for Q2; and 1.06, 0.70-1.62 for Q3, compared with Q4 [p = 0.10]), but no association with cognitive decline by Trails B. Conclusion: We found little evidence of independent associations between lower 25-hydroxyvitamin D level and baseline global and executive cognitive function or incident cognitive decline. Neurology (R) 2010;74:33-41

引用

页码：33 / 41

页数：9