Endosome-specific localization and function of the ARF activator GNOM

被引：19

作者：

Bonifacino, JS ^{[1
]}

Jackson, CL ^{[1
]}

机构：

[1] NICHHD, Cell Biol & Metab Branch, NIH, Bethesda, MD 20892 USA

来源：

CELL | 2003年 / 112卷 / 02期

关键词：

D O I：

10.1016/S0092-8674(03)00038-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

ARF GTPases act at multiple steps of the secretory and vacuolar/lysosomal trafficking pathways, but little is known about the spatial regulation of ARF activation. In this issue of Cell, Geldner et al. demonstrate that the Arabidopsis ARF activator GNOM localizes to endosomes where it controls the polarized trafficking of the auxin efflux carrier PIN1 to the basal plasma membrane.

引用

页码：141 / 142

页数：2

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