Monocytes from type 2 diabetic patients have a pro-inflammatory profile -: 1,25-Dihydroxyvitamin D3 works as anti-inflammatory

被引：321

作者：

Giulietti, Annapaula ^{[1
]}

van Etten, Evelyne ^{[1
]}

Overbergh, Lut ^{[1
]}

Stoffels, Katinka ^{[1
]}

Bouillon, Roger ^{[1
]}

Mathieu, Chantal ^{[1
]}

机构：

[1] Catholic Univ Louvain, Lab Expt Med & Endocrinol, B-3000 Louvain, Belgium

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 2007年 / 77卷 / 01期

关键词：

atherosclerosis; cytokines; inflammation; monocytes; type; 2; diabetes; vitamin D; NECROSIS-FACTOR-ALPHA; INTERCELLULAR-ADHESION MOLECULE-1; HUMAN ENDOTHELIAL-CELLS; INSULIN-RESISTANCE; VITAMIN-D; ATHEROSCLEROSIS RISK; ADIPOSE-TISSUE; IMMUNE-SYSTEM; TNF-ALPHA; INTERFERON-GAMMA;

D O I：

10.1016/j.diabres.2006.10.007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The exact factors contributing to the pathogenesis of type 2 diabetes remain elusive. Lately, it was suggested that inflammation and activation of the innate immune system could be linked to type 2 diabetes pathogenesis and also to the development of common diabetic complications, mainly atherosclerosis. The aim of this study was to investigate the role of monocytes in this sub-clinical inflammatory state and test 1,25-dihydroxyvitamin D-3, the active form of Vitamin D, as an anti-inflammatory agent. For this purpose, monocytes from type 2 diabetic patients were compared to monocytes from healthy controls and type 1 diabetic patients. The expression profile of inflammatory markers in freshly isolated and immune-stimulated monocytes was measured by quantitative real-time RT-PCR. Type 2 diabetic patients showed significantly higher expression levels of TNF-alpha, IL-6, IL-1, IL-8, COX-2, ICAM-1 and B7-1 compared to controls and type I diabetic patients. 1,25-Dihydroxyvitamin D3 was able to down-regulate the expression of TNF-alpha, IL-6, IL-1, and IL-8, confirming its immunomodulatory properties. From these data we concluded that monocytes from type 2 diabetic patients have a pro-inflammatory profile. In addition, 1,25-dihydroxyvitamin D3 was able to modulate inflammation in these monocytes. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：47 / 57

页数：11

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