Susceptibility of human and murine Chlamydia trachomatis serovars to granulocyte- and epithelium-derived antimicrobial peptides

被引：20

作者：

Chong-Cerrillo, C ^{[1
]}

Selsted, ME ^{[1
]}

Peterson, EM ^{[1
]}

de la Maza, LM ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Pathol Med Sci, Irvine, CA 92697 USA

来源：

JOURNAL OF PEPTIDE RESEARCH | 2003年 / 61卷 / 05期

关键词：

antimicrobial peptides; Chlamydia trachomatis; cryptdin-4; indolicidin; protegrin-1; RTD-1;

D O I：

10.1034/j.1399-3011.2003.00053.x

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Four antimicrobial peptides, protegrin-1, RTD-1, cryptdin-4, and indolicidin, were tested for their ability to inhibit the in vitro growth of Chlamydia trachomatis serovars E, L2, and mouse pneumonitis (MoPn). In general, protegrin-1 was found to have the strongest anti-chlamydial activity. Overall, of the three serovars tested, L2 was the most susceptible while MoPn was the most resistant to these peptides.

引用

页码：237 / 242

页数：6

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