Prostate cancer and the Met hepatocyte growth factor receptor

被引：74

作者：

Knudsen, BS ^{[1
]}

Edlund, M

机构：

[1] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98125 USA

[2] Emory Univ, Dept Urol, Mol & Therapeut Program, Winship Canc Inst,Sch Med, Atlanta, GA 30322 USA

来源：

ADVANCES IN CANCER RESEARCH, VOL 91 | 2004年 / 91卷

关键词：

D O I：

10.1016/S0065-230X(04)91002-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The hepatocyte growth factor/scatter factor (HGF/SF) and its receptor the Met protein tyrosine kinase, form a classic ligand-receptor system for epithelial-mesenchymal communications in the normal and cancerous prostate. This review iflustrates the expression and activities of HGF/SF and Met during prostate development, homeostasis, and carcinogenesis. The participation of HGF/SF in the morphogenetic program of rodent prostate development, the role of Met in normal human prostate epithelium, and underlying mechanisms of deregulated Met expression in localized and metastatic prostate cancer are discussed. On the basis of the commonly observed overexpression of Met in metastatic prostate cancer, HGF/SF-Met-targeted imaging and therapeutic agents can now be applied toward diagnosis and treatment. (C) 2004 Elsevier Inc.

引用

页码：31 / 67

页数：37

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