Progress toward the clinical application of patient-specific pluripotent stem cells

被引：269

作者：

Kiskinis, Evangelos ^{[1
]}

Eggan, Kevin ^{[1
]}

机构：

[1] Harvard Univ, Stowers Med Inst, Harvard Stem Cell Inst, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2010年 / 120卷 / 01期

关键词：

HUMAN SOMATIC-CELLS; MOTOR-NEURONS; HUMAN FIBROBLASTS; GENE-EXPRESSION; GENERATION; MOUSE; INDUCTION; MURINE; MODEL; MICE;

D O I：

10.1172/JCI40553

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Induced pluripotent stem (iPS) cells are generated by epigenetic reprogramming of somatic cells through the exogenous expression of transcription factors. These cells, just like embryonic stem cells, are likely to have a major impact on regenerative medicine, because they self-renew and retain the potential to be differentiated into all cell types of the human body. In this Review, we describe the current state of iPS cell technology, including approaches by which they are generated and what is known about their biology, and discuss the potential applications of these cells for disease modeling, drug discovery, and, eventually, cell replacement therapy.

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页码：51 / 59

页数：9

相关论文

共 101 条

[61] Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons [J].

Nagai, Makiko ;

Re, Diane B. ;

Nagata, Tetsuya ;

Chalazonitis, Alcmene ;

Jessell, Thomas M. ;

Wichterle, Hynek ;

Przedborski, Serge .

NATURE NEUROSCIENCE, 2007, 10 (05) :615-622

[62] Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts [J].

Nakagawa, Masato ;

Koyanagi, Michiyo ;

Tanabe, Koji ;

Takahashi, Kazutoshi ;

Ichisaka, Tomoko ;

Aoi, Takashi ;

Okita, Keisuke ;

Mochiduki, Yuji ;

Takizawa, Nanako ;

Yamanaka, Shinya .

NATURE BIOTECHNOLOGY, 2008, 26 (01) :101-106

[63] Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4 [J].

Nichols, J ;

Zevnik, B ;

Anastassiadis, K ;

Niwa, H ;

Klewe-Nebenius, D ;

Chambers, I ;

Schöler, H ;

Smith, A .

CELL, 1998, 95 (03) :379-391

[64] Generation of Mouse Induced Pluripotent Stem Cells Without Viral Vectors [J].

Okita, Keisuke ;

Nakagawa, Masato ;

Hong, Hyenjong ;

Ichisaka, Tomoko ;

Yamanaka, Shinya .

SCIENCE, 2008, 322 (5903) :949-953

[65] Generation of germline-competent induced pluripotent stem cells [J].

Okita, Keisuke ;

Ichisaka, Tomoko ;

Yamanaka, Shinya .

NATURE, 2007, 448 (7151) :313-U1

[66] Disease-specific induced pluripotent stem cells [J].

Park, In-Hyun ;

Arora, Natasha ;

Huo, Hongguang ;

Maherali, Nimet ;

Ahfeldt, Tim ;

Shimamura, Akiko ;

Lensch, M. William ;

Cowan, Chad ;

Hochedlinger, Konrad ;

Daley, George Q. .

CELL, 2008, 134 (05) :877-886

[67]

Park IH, 2008, NATURE, V451, P141, DOI [10.1038/nature06534, 10.1038/natureO6534]

[68] Epigenetic Modifiers: Basic Understanding and Clinical Development [J].

Piekarz, Richard L. ;

Bates, Susan E. .

CLINICAL CANCER RESEARCH, 2009, 15 (12) :3918-3926

[69] Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells [J].

Raya, Angel ;

Rodriguez-Piza, Ignasi ;

Guenechea, Guillermo ;

Vassena, Rita ;

Navarro, Susana ;

Jose Barrero, Maria ;

Consiglio, Antonella ;

Castella, Maria ;

Rio, Paula ;

Sleep, Eduard ;

Gonzalez, Federico ;

Tiscornia, Gustavo ;

Garreta, Elena ;

Aasen, Trond ;

Veiga, Anna ;

Verma, Inder M. ;

Surralles, Jordi ;

Bueren, Juan ;

Izpisua Belmonte, Juan Carlos .

NATURE, 2009, 460 (7251) :53-U61

[70] Correction of a genetic defect by nuclear transplantation and combined cell and gene therapy [J].

Rideout, WM ;

Hochedlinger, K ;

Kyba, M ;

Daley, GQ ;

Jaenisch, R .

CELL, 2002, 109 (01) :17-27

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