Nucleic acid aptamers as antithrombotic agents: Opportunities in extracellular therapeutics

被引：38

作者：

Becker, Richard C. ^{[1
]}

Povsic, Thomas ^{[2
]}

Cohen, Mauricio G. ^{[3
,4
]}

Rusconi, Christopher P. ^{[5
]}

Sullenger, Bruce ^{[6
]}

机构：

[1] Duke Univ, Med Ctr, Biosignatures Program, Duke Clin Res Inst,Cardiovasc Thrombosis Res Ctr, Durham, NC 27715 USA

[2] Duke Univ, Med Ctr, Div Cardiol, Durham, NC 27715 USA

[3] Univ Miami, Miller Sch Med, Miami, FL 33136 USA

[4] Univ Miami Hosp, Cardiac Catheterizat Lab, Miami, FL USA

[5] Regado Biosci Inc, Durham, NC USA

[6] Duke Univ, Med Ctr, Dept Genet, Ctr Genet & Cellular Therapies, Durham, NC 27715 USA

来源：

THROMBOSIS AND HAEMOSTASIS | 2010年 / 103卷 / 03期

关键词：

Nucleic acids; RNA and DNA aptamers; protein-binding oligonucleotides; anticoagulant therapy; VON-WILLEBRAND-FACTOR; FACTOR-IXA ACTIVITY; THROMBIN INHIBITOR; RNA APTAMERS; BETA-3-INTEGRIN-DEFICIENT MICE; CARDIOPULMONARY BYPASS; IN-VIVO; ANTIDOTE; GENERATION; SELECTION;

D O I：

10.1160/TH09-10-0716

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Antithrombotic therapy for the acute management of thrombotic disorders has been stimulated and guided actively by our current understanding of platelet biology, coagulation proteases, and vascular science. A translatable platform for coagulation, based soundly on biochemistry, enzymology and cellular events on platelets and tissue factor-baring cells, introduces fundamental constructs, mechanistic clarity, clinical investigation of both disease- and patient-specific therapies. In the current review, we build upon and expand substantially our observations surrounding nucleic acids as antithrombotic agents.

引用

页码：586 / 595

页数：10

共 37 条

[1] Glycoprotein Ib-IX-V [J].

Andrews, RK ;

Gardiner, EE ;

Shen, Y ;

Whisstock, JC ;

Berndt, MC .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2003, 35 (08) :1170-1174

[2] Nucleic acid aptamers in therapeutic anticoagulation - Technology, development and clinical application [J].

Becker, RC ;

Rusconi, C ;

Sullenger, B .

THROMBOSIS AND HAEMOSTASIS, 2005, 93 (06) :1014-1020

[3] SELECTION OF SINGLE-STRANDED-DNA MOLECULES THAT BIND AND INHIBIT HUMAN THROMBIN [J].

BOCK, LC ;

GRIFFIN, LC ;

LATHAM, JA ;

VERMAAS, EH ;

TOOLE, JJ .

NATURE, 1992, 355 (6360) :564-566

[4] A randomized, repeat-dose, pharmacodynamic and safety study of an antidote-controlled factor IXa inhibitor [J].

Chan, M. Y. ;

Rusconi, C. P. ;

Alexander, J. H. ;

Tonkens, R. M. ;

Harrington, R. A. ;

Becker, R. C. .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2008, 6 (05) :789-796

[5] Phase 1b randomized study of antidote-controlled modulation of factor IXa activity in patients with stable coronary artery disease [J].

Chan, Mark Y. ;

Cohen, Mauricio G. ;

Dyke, Christopher K. ;

Myles, Shelley K. ;

Aberle, Laura G. ;

Lin, Min ;

Walder, James ;

Steinhubl, Steven R. ;

Gilchrist, Ian C. ;

Kleiman, Neal S. ;

Vorchheimer, David A. ;

Chronos, Nicholas ;

Melloni, Chiara ;

Alexander, John H. ;

Harrington, Robert A. ;

Tonkens, Ross M. ;

Becker, Richard C. ;

Rusconi, Christopher P. .

CIRCULATION, 2008, 117 (22) :2865-2874

[6]

Cohen MG, 2009, EUR HEART J, V30, P101

[7]

Dausse Eric, 2005, V288, P391

[8] PILOT-STUDY OF THE EFFICACY OF A THROMBIN INHIBITOR FOR USE DURING CARDIOPULMONARY BYPASS [J].

DEANDA, A ;

COUTRE, SE ;

MOON, MR ;

VIAL, CM ;

GRIFFIN, LC ;

LAW, VS ;

KOMEDA, M ;

LEUNG, LLK ;

MILLER, DC .

ANNALS OF THORACIC SURGERY, 1994, 58 (02) :344-350

[9] SELECTION OF AN RNA MOLECULE THAT MIMICS A MAJOR AUTOANTIGENIC EPITOPE OF HUMAN INSULIN-RECEPTOR [J].

DOUDNA, JA ;

CECH, TR ;

SULLENGER, BA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (06) :2355-2359

[10]

Dua Pooja, 2008, Recent Pat DNA Gene Seq, V2, P172, DOI 10.2174/187221508786241710

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