Glycoprotein Ib-IX-V

被引：159

作者：

Andrews, RK ^{[1
]}

Gardiner, EE

Shen, Y

Whisstock, JC

Berndt, MC

机构：

[1] Monash Univ, Vasc Biol Lab, Dept Biochem & Mol Biol, Clayton, Vic 3168, Australia

[2] Monash Univ, Dept Biochem & Mol Biol, Struct Biol Lab, Clayton, Vic 3168, Australia

[3] Monash Univ, Victorian Bioinformat Consortium, Clayton, Vic 3168, Australia

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2003年 / 35卷 / 08期

关键词：

glycoprotein Ib-IX-V; von Willebrand factor; platelets; thrombosis;

D O I：

10.1016/S1357-2725(02)00280-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glycoprotein (GP) Ib-IX-V is a remarkable platelet adhesion receptor of the leucine-rich repeat family. It has evolved to fulfil its major function of initiating platelet aggregation (thrombus formation) at high-shear stress in flowing blood. In addition to binding von Willebrand factor (vWF) in subendothelial matrix or plasma to trigger platelet aggregation, GPIb-IX-V also binds counter-receptors, alphaMbeta2 (Mac-1) on neutrophils or P-selectin on activated platelets or endothelial cells. GPIb-IX-V ligands also include alpha-thrombin, clotting factors XI/XIIa, and high-molecular-weight kininogen. Interactions involving GPIb-IX-V are therefore central to vascular processes of thrombosis and inflammation, and the receptor is under intense scrutiny as a potential therapeutic target. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：1170 / 1174

页数：5

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