PELP1: A Novel Therapeutic Target for Hormonal Cancers

被引：27

作者：

Chakravarty, Dimple ^{[1
]}

Tekmal, Rajeshwar Rao ^{[1
]}

Vadlamudi, Ratna K. ^{[1
]}

机构：

[1] Univ Texas Hlth Sci Ctr San Antonio, Dept Obstet & Gynecol, San Antonio, TX 78229 USA

来源：

IUBMB LIFE | 2010年 / 62卷 / 03期

关键词：

estrogen receptor; coregulators; PELP1; hormonal signaling; therapy resistance; GLUTAMIC-ACID-RICH; RECEPTOR COACTIVATOR PELP1/MNAR; GROWTH-FACTOR REGULATION; RETRACTED ARTICLE. SEE; ESTROGEN-RECEPTOR; BREAST-CANCER; PROLINE-RICH; NONGENOMIC ACTIVITY; INTERACTING PROTEIN; COREGULATOR PELP1;

D O I：

10.1002/iub.287

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent studies implicate that the estrogen receptor (ER) coregulator proline-, glutamic acid-, and leucine-rich protein (PELP) 1 as playing critical roles in ER-genomic, ER-nongenomic, and ER-signaling cross talk with growth factor signaling pathways. PELP1 expression is deregulated in hormonal cancers and recent studies further elucidated the molecular mechanisms by which PELP1 regulates hormone therapy response. Although PELP1 is important for normal functions of the ER, the possibility to target ER-PELP1 axis appears to be an effective strategy for preventing hormonal carcinogenesis and therapy resistance. Thus, PELP1 may be useful as prognostic marker for hormonal cancers and PELP1 signaling may be useful to generate targeted therapeutics to overcome hormonal therapy resistance. (C) 2009 IUBMB IUBMB Life, 62(3): 163-169, 2010

引用

页码：163 / 169

页数：7

共 65 条

[1] Intracellular signal transduction pathway proteins as targets for cancer therapy [J].

Adjei, AA ;

Hidalgo, M .

JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (23) :5386-5403

[2] Functional interactions between the estrogen receptor coactivator PELP1/MNAR and retinoblastoma protein [J].

Balasenthil, S ;

Vadlamudi, RK .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (24) :22119-22127

[3] Characterization of the interactions of estrogen receptor and MNAR in the activation of cSrc [J].

Barletta, F ;

Wong, CW ;

McNally, C ;

Komm, BS ;

Katzenellenbogen, B ;

Cheskis, BJ .

MOLECULAR ENDOCRINOLOGY, 2004, 18 (05) :1096-1108

[4] Novel estrogen receptor coregulators and signaling molecules in human diseases [J].

Barnes, CJ ;

Vadlamudi, RK ;

Kumar, R .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2004, 61 (03) :281-291

[5] Mechanisms of estrogen receptor signaling:: Convergence of genomic and nongenomic actions on target genes [J].

Björnström, L ;

Sjöberg, M .

MOLECULAR ENDOCRINOLOGY, 2005, 19 (04) :833-842

[6]

CHAKRAVARTY C, 2009, P AM ASSOC CANC RES, P2387

[7]

Chakravarty D, 2009, CANCER RES, V69, p311S

[8]

CHAKRAVARTY D, 2008, P AM ASSOC CANC RES, P5451

[9] Soft-particle model analysis of effect of LPS on electrophoretic softness of Acidithiobacillus ferrooxidans grown in presence of different metal ions [J].

Chandraprabha, M. N. ;

Modak, J. M. ;

Natarajan, K. A. .

COLLOIDS AND SURFACES B-BIOINTERFACES, 2009, 69 (01) :1-7

[10] MNAR plays an important role in ERa activation of Src/MAPK and PI3K/Akt signaling pathways [J].

Cheskis, Boris J. ;

Greger, James ;

Cooch, Neil ;

McNally, Christopher ;

Mclarney, Sean ;

Lam, Ho-Sun ;

Rutledge, Su ;

Mekonnen, Belew ;

Hauze, Diane ;

Nagpal, Sunil ;

Freedman, Leonard P. .

STEROIDS, 2008, 73 (9-10) :901-905

← 1 2 3 4 5 6 7 →