△FosB:: a molecular switch for long-term adaptation in the brain

被引：313

作者：

McClung, CA

Ulery, PG

Perrotti, LI

Zachariou, V

Berton, O

Nestler, EJ ^{[1
]}

机构：

[1] Univ Texas, SW Med Ctr, Dept Psychiat, Dallas, TX 75390 USA

[2] Univ Texas, SW Med Ctr, Ctr Basic Neurosci, Dallas, TX 75390 USA

来源：

MOLECULAR BRAIN RESEARCH | 2004年 / 132卷 / 02期

关键词：

triangle FosB; Fos family proteins; amino acids;

D O I：

10.1016/j.molbrainres.2004.05.014

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

DeltaFosB is a unique transcription factor that plays an essential role in long-term adaptive changes in the brain associated with diverse conditions, such as drug addiction, Parkinson's disease, depression, and antidepressant treatment. It is induced in brain, in a region- and cell-type-specific manner by many types of chronic perturbations. Once induced, it persists for long periods of time due to its unusual stability. The transcriptional effects of DeltaFosB are complex, because the protein can function as both a transcriptional activator and repressor. Progress has been made in identifying specific target genes for DeltaFosB and in relating some of these genes to DeltaFosB's cellular and behavioral actions. Future studies will help us to better understand the biochemical basis of DeltaFosB's unique stability, as well as the precise molecular pathways through which this transcription factor produces its complex effects on neuronal plasticity and complex behavior. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：146 / 154

页数：9

共 58 条

[1] Time course of striatal ΔFosB-like immunoreactivity and prodynorphin mRNA levels after discontinuation of chronic dopaminomimetic treatment [J].