Tumorigenesis - A checkpoint on the road to cancer

被引：120

作者：

Orr-Weaver, TL ^{[1
]}

Weinberg, RA

机构：

[1] MIT, Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

[2] MIT, Dept Biol, Cambridge, MA 02142 USA

来源：

NATURE | 1998年 / 392卷 / 6673期

关键词：

D O I：

10.1038/32520

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Mutations that disrupt a cell-division checkpoint, thereby causing alterations in chromosome number, have been identified in cancer cells. The accompanying increase in mutability helps to explain how tumours acquire large numbers of mutant genes during their development.

引用

页码：223 / 224

页数：2

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