The SYK tyrosine kinase: a crucial player in diverse biological functions

被引：1018

作者：

Mocsai, Attila ^{[1
]}

Ruland, Juergen ^{[2
,3
]}

Tybulewicz, Victor L. J. ^{[4
]}

机构：

[1] Semmelweis Univ, Sch Med, Dept Physiol, H-1094 Budapest, Hungary

[2] Tech Univ Munich, Klinikum Rechts Isar, Med Klin 3, Inst Mol Immunol, D-81675 Munich, Germany

[3] German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Lab Signalling Immune Syst, D-85764 Neuherberg, Germany

[4] MRC Natl Inst Med Res, Div Immune Cell Biol, London NW7 1AA, England

来源：

NATURE REVIEWS IMMUNOLOGY | 2010年 / 10卷 / 06期

基金：

英国惠康基金; 英国医学研究理事会; 欧洲研究理事会;

关键词：

C-TYPE LECTIN; B-CELL DEVELOPMENT; NF-KAPPA-B; RECEPTOR GAMMA-CHAIN; FC-EPSILON-RI; PATTERN-RECOGNITION RECEPTOR; SEVERE COMBINED IMMUNODEFICIENCY; PHOSPHOTYROSINE-BINDING DOMAIN; ACUTE LYMPHOBLASTIC-LEUKEMIA; CHRONIC LYMPHOCYTIC-LEUKEMIA;

D O I：

10.1038/nri2765

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Spleen tyrosine kinase (SYK) is known to have a crucial role in adaptive immune receptor signalling. However, recent reports indicate that SYK also mediates other, unexpectedly diverse biological functions, including cellular adhesion, innate immune recognition, osteoclast maturation, platelet activation and vascular development. SYK is activated by C-type lectins and integrins, and activates new targets, including the CARD9-BCL-10-MALT1 pathway and the NLRP3 inflammasome. Studies using Drosophila melanogaster suggest that there is an evolutionarily ancient origin of SYK-mediated signalling. Moreover, SYK has a crucial role in autoimmune diseases and haematological malignancies. This Review summarizes our current understanding of the diverse functions of SYK and how this is being translated for therapeutic purposes.

引用

页码：387 / 402

页数：16

共 190 条

[51] A Homozygous CARD9 Mutation in a Family with Susceptibility to Fungal Infections [J].

Glocker, Erik-Oliver ;

Hennigs, Andre ;

Nabavi, Mohammad ;

Schaeffer, Alejandro A. ;

Woellner, Cristina ;

Salzer, Ulrich ;

Pfeifer, Dietmar ;

Veelken, Hendrik ;

Warnatz, Klaus ;

Tahami, Fariba ;

Jamal, Sarah ;

Manguiat, Annabelle ;

Rezaei, Nima ;

Amirzargar, Ali Akbar ;

Plebani, Alessandro ;

Hannesschlaeger, Nicole ;

Gross, Olaf ;

Ruland, Juergen ;

Grimbacher, Bodo .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (18) :1727-1735

[52] Spleen tyrosine kinase (Syk) deficiency in childhood pro-B cell acute lymphoblastic leukemia [J].

Goodman, PA ;

Wood, CM ;

Vassilev, A ;

Mao, C ;

Uckun, FM .

ONCOGENE, 2001, 20 (30) :3969-3978

[53] Dectin-1 stimulation by Candida albicans yeast or zymosan triggers NFAT activation in macrophages and dendritic cells [J].

Goodridge, Helen S. ;

Simmons, Randi M. ;

Underhill, David M. .

JOURNAL OF IMMUNOLOGY, 2007, 178 (05) :3107-3115

[54] An ITAM-signaling pathway controls cross-presentation of particulate but not soluble antigens in dendritic cells [J].

Graham, Daniel B. ;

Stephenson, Linda M. ;

Lam, Siu Kit ;

Brim, Karry ;

Lee, Hyang Mi ;

Bautista, Jhoanne ;

Gilfillan, Susan ;

Akilesh, Shreeram ;

Fujikawa, Keiko ;

Swat, Wojciech .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (12) :2889-2897

[55] Structural basis for the requirement of two phosphotyrosine residues in signaling mediated by Syk tyrosine kinase [J].

Groesch, TD ;

Zhou, F ;

Mattila, S ;

Geahlen, RL ;

Post, CB .

JOURNAL OF MOLECULAR BIOLOGY, 2006, 356 (05) :1222-1236

[56] Multiple ITAM-coupled NK-cell receptors engage the Bcl10/Malt1 complex via Carma1 for NF-κB and MAPK activation to selectively control cytokine production [J].

Gross, Olaf ;

Grupp, Christina ;

Steinberg, Christian ;

Zimmermann, Stephanie ;

Strasser, Dominikus ;

Hannesschlaeger, Nicole ;

Reindl, Wolfgang ;

Jonsson, Helena ;

Huo, Hairong ;

Littman, Dan R. ;

Peschel, Christian ;

Yokoyama, Wayne M. ;

Krug, Anne ;

Ruland, Juergen .

BLOOD, 2008, 112 (06) :2421-2428

[57] Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity [J].

Gross, Olaf ;

Gewies, Andreas ;

Finger, Katrin ;

Schaefer, Martin ;

Sparwasser, Tim ;

Peschel, Christian ;

Forster, Irmgard ;

Ruland, Juergen .

NATURE, 2006, 442 (7103) :651-656

[58] Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence [J].

Gross, Olaf ;

Poeck, Hendrik ;

Bscheider, Michael ;

Dostert, Catherine ;

Hannesschlaeger, Nicole ;

Endres, Stefan ;

Hartmann, Gunther ;

Tardivel, Aubry ;

Schweighoffer, Edina ;

Tybulewicz, Victor ;

Mocsai, Attila ;

Tschopp, Juerg ;

Ruland, Juergen .

NATURE, 2009, 459 (7245) :433-U149

[59] Thermodynamic study of the binding of the tandem-SH2 domain of the Syk kinase to a dually phosphorylated ITAM peptide:: Evidence for two conformers [J].

Grucza, RA ;

Fütterer, K ;

Chan, AC ;

Waksman, G .

BIOCHEMISTRY, 1999, 38 (16) :5024-5033

[60] Cutting edge: Constitutive B cell receptor signaling is critical for basal growth of B lymphoma [J].

Gururajan, Murali ;

Jennings, C. Darrel ;

Bondada, Subbarao .

JOURNAL OF IMMUNOLOGY, 2006, 176 (10) :5715-5719

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