The membrane-bound bile acid receptor TGR5 (Gpbar-1) is localized in the primary cilium of cholangiocytes

被引：124

作者：

Keitel, Verena ^{[1
]}

Ullmer, Christoph ^{[2
]}

Haeussinger, Dieter ^{[1
]}

机构：

[1] Univ Dusseldorf, Clin Gastroenterol Hepatol & Infectiol, D-40225 Dusseldorf, Germany

[2] F Hoffmann La Roche & Cie AG, Dept Vasc & Metab Dis, Div Pharmaceut, CH-4070 Basel, Switzerland

来源：

BIOLOGICAL CHEMISTRY | 2010年 / 391卷 / 07期

关键词：

bile acids; bile flow; liver; TRANSPORT PROTEINS; EPITHELIAL-CELLS; NEURONAL CILIA; DETECT CHANGES; EXPRESSION; RAT; FLOW;

D O I：

10.1515/BC.2010.077

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Cholangiocyte cilia are sensory organelles that extend from the apical membrane into the bile duct lumen and detect changes in bile flow and osmolarity. Whether or not cholangiocyte cilia are responsive to bile acids is unknown. TGR5 (Gpbar-1) is a membrane-bound bile acid receptor which is expressed in biliary epithelial cells and promotes chloride secretion in gallbladder epithelial cells. As shown in the present study. TGR5 is localized in the primary cilium of mouse and human cholangiocytes. Here the receptor could play an important role in coupling biliary bile acid concentration and composition to ductular bile formation.

引用

页码：785 / 789

页数：5

共 33 条

[1]

Taurohyodeoxycholate- and tauroursodeoxycholate-induced hypercholeresis is augmented in duct ligated rats [J].

Baiocchi, L ;

Alpini, G ;

Glaser, S ;

Angelico, M ;

Alvaro, D ;

Francis, H ;

Marzioni, M ;

Phinizy, JL ;

Barbaro, B ;

LeSage, G .

JOURNAL OF HEPATOLOGY, 2003, 38 (02) :136-147

[2]

RAPID ACTIVATION OF ALTERNATIVE 2ND MESSENGER PATHWAYS IN OLFACTORY CILIA FROM RATS BY DIFFERENT ODORANTS [J].

BOEKHOFF, I ;

TAREILUS, E ;

STROTMANN, J ;

BREER, H .

EMBO JOURNAL, 1990, 9 (08) :2453-2458

[3]

Localization of 5-HT6 receptors at the plasma membrane of neuronal cilia in the rat brain [J].

Brailov, I ;

Bancila, M ;

Brisorgueil, MJ ;

Miquel, MC ;

Hamon, M ;

Vergé, D .

BRAIN RESEARCH, 2000, 872 (1-2) :271-275

[4]

BRONSHTEIN AA, 1977, TSITOLOGIYA+, V19, P33

[5]

Sensory cilia and integration of signal transduction in human health and disease [J].

Christensen, Soren T. ;

Pedersen, Lotte B. ;

Schneider, Linda ;

Satir, Peter .

TRAFFIC, 2007, 8 (02) :97-109

[6]

Effects of angiogenic factor overexpression by human and rodent cholangiocytes in polycystic liver diseases [J].

Fabris, L ;

Cadamuro, M ;

Fiorotto, R ;

Roskams, T ;

Spirlì, C ;

Melero, S ;

Sonzogni, A ;

Joplin, RE ;

Okolicsanyi, L ;

Strazzabosco, M .

HEPATOLOGY, 2006, 43 (05) :1001-1012

[7]

Heterogeneity of the intrahepatic biliary epithelium [J].

Glaser, Shannon ;

Francis, Heather ;

DeMorrow, Sharon ;

LeSage, Gene ;

Fava, Giammarco ;

Marzioni, Marco ;

Venter, Julie ;

Alpini, Gianfranco .

WORLD JOURNAL OF GASTROENTEROLOGY, 2006, 12 (22) :3523-3536

[8]

Cholangiocyte cilia express TRPV4 and detect changes in luminal tonicity inducing bicarbonate secretion [J].

Gradilone, Sergio A. ;

Masyuk, Anatoliy I. ;

Splinter, Patrick L. ;

Banales, Jesus M. ;

Huang, Bing Q. ;

Tietz, Pamela S. ;

Masyuk, Tatyana V. ;

LaRusso, Nicholas F. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (48) :19138-19143

[9]

GRISHAM JW, 1963, P SOC EXP BIOL MED, V114, P318

[10]

Selective targeting of somatostatin receptor 3 to neuronal cilia [J].

Händel, M ;

Schulz, S ;

Stanarius, A ;

Schreff, M ;

Erdtmann-Vourliotis, M ;

Schmidt, H ;

Wolf, G ;

Höllt, V .

NEUROSCIENCE, 1999, 89 (03) :909-926

← 1 2 3 4 →