Chemotherapy-induced resistance by ATP-binding cassette transporter genes

被引：316

作者：

Gillet, Jean-Pierre

Efferth, Thomas

Remacle, Jose

机构：

[1] Univ Namur, Dept Biol, B-5000 Namur, Belgium

[2] German Canc Res Ctr, D-69120 Heidelberg, Germany

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2007年 / 1775卷 / 02期

关键词：

ABC transporter genes; multidrug resistance; P-GLYCOPROTEIN EXPRESSION; ORGANIC ANION TRANSPORTER; ACUTE MYELOID-LEUKEMIA; SALT EXPORT PUMP; PERSISTENT HYPERINSULINEMIC HYPOGLYCEMIA; X-LINKED ADRENOLEUKODYSTROPHY; ACUTE LYMPHOBLASTIC-LEUKEMIA; MESSENGER-RNA EXPRESSION; DUBIN-JOHNSON-SYNDROME; CANCER CELL-LINE;

D O I：

10.1016/j.bbcan.2007.05.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A key issue in the treatment of many cancers is the development of resistance to chemotherapeutic drugs. Resistance mechanisms are numerous and complex. One of them is mediated by the overexpression of ATP-binding cassette (ABC) transporters able to efflux drugs out of the tumor cell. The last two decades have seen notable growth of knowledge concerning the involvement of ABC transporters in resistance to chemotherapy. This review emphasizes these transporters, their clinical relevance and the diagnostic methods and strategies to circumvent multidrug resistance (MDR) mediated by ABC transporters. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：237 / 262

页数：26

共 382 条

[71] Structure, function, expression, genomic organization, and single nucleotide polymorphisms of human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP) efflux transporters [J].