Manipulating dendritic cell biology for the active immunotherapy of cancer

被引：252

作者：

O'Neill, DW ^{[1
]}

Adams, S ^{[1
]}

Bhardwaj, N ^{[1
]}

机构：

[1] NYU, Sch Med, Inst Canc, Tumor Vaccine Ctr, New York, NY 10016 USA

来源：

BLOOD | 2004年 / 104卷 / 08期

关键词：

D O I：

10.1182/blood-2003-12-4392

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Dendritic cells (DCs) are specialized antigen-presenting cells (APCs) that have an unequaled capacity to initiate primary immune responses, including tolerogenic responses. Because of the importance of DCs in the induction and control of immunity, an understanding of their biology is central to the development of potent immunotherapies for cancer, chronic infections, autoimmune disease, and induction of transplantation tolerance. This review discusses recent advances in DC research and the application of this knowledge toward new strategies for the clinical manipulation of DCs for cancer immunotherapy. (C) 2004 by The American Society of Hematology.

引用

页码：2235 / 2246

页数：12

共 161 条

[41] Modulation of tryptophan catabolism by regulatory T cells [J].

Fallarino, F ;

Grohmann, U ;

Hwang, KW ;

Orabona, C ;

Vacca, C ;

Bianchi, R ;

Belladonna, ML ;

Fioretti, MC ;

Alegre, ML ;

Puccetti, P .

NATURE IMMUNOLOGY, 2003, 4 (12) :1206-1212

[42] NK cell compartments and their activation by dendritic cells [J].

Ferlazzo, G ;

Münz, C .

JOURNAL OF IMMUNOLOGY, 2004, 172 (03) :1333-1339

[43] Cancer vaccines: Between the idea and the reality [J].

Finn, OJ .

NATURE REVIEWS IMMUNOLOGY, 2003, 3 (08) :630-641

[44] Dendritic cell-based xenoantigen vaccination for prostate cancer immunotherapy [J].

Fong, L ;

Brockstedt, D ;

Benike, C ;

Breen, JK ;

Strang, G ;

Ruegg, CL ;

Engleman, EG .

JOURNAL OF IMMUNOLOGY, 2001, 167 (12) :7150-7156

[45] Dendritic cells injected via different routes induce immunity in cancer patients [J].

Fong, L ;

Brockstedt, D ;

Benike, C ;

Wu, L ;

Engleman, EG .

JOURNAL OF IMMUNOLOGY, 2001, 166 (06) :4254-4259

[46] Altered peptide ligand vaccination with Flt3 ligand expanded dendritic cells for tumor immunotherapy [J].

Fong, L ;

Hou, YF ;

Rivas, A ;

Benike, C ;

Yuen, A ;

Fisher, GA ;

Davis, MM ;

Engleman, EG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (15) :8809-8814

[47] Activation of influenza virus-specific CD4+ and CD8+ T cells:: a new role for plasmacytoid denchitic cells in adaptive immunity [J].

Fonteneau, JF ;

Gilliet, M ;

Larsson, M ;

Dasilva, I ;

Münz, C ;

Liu, YJ ;

Bhardwaj, N .

BLOOD, 2003, 101 (09) :3520-3526

[48] Interactions between dead cells and dendritic cells in the induction of antiviral CTL responses [J].

Fonteneau, JF ;

Larsson, M ;

Bhardwaj, N .

CURRENT OPINION IN IMMUNOLOGY, 2002, 14 (04) :471-477

[49] Activation of natural killer T cells by α-galactosylceramide rapidly induces the full maturation of dendritic cells in vivo and thereby acts as an adjuvant for combined CD4 and CD8 T cell immunity to a coadministered protein [J].

Fujii, S ;

Shimizu, K ;

Smith, C ;

Bonifaz, L ;

Steinman, RM .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 198 (02) :267-279

[50] CD83 expression influences CD4+ T cell development in the thymus [J].

Fujimoto, Y ;

Tu, LL ;

Miller, AS ;

Bock, C ;

Fujimoto, M ;

Doyle, C ;

Steeber, DA ;

Tedder, TF .

CELL, 2002, 108 (06) :755-767

← 1 2 3 4 5 6 7 8 9 10 →