The biology of metastasis to a sanctuary site

被引：114

作者：

Palmieri, Diane

Chambers, Ann F.

Felding-Habermann, Brunhilde

Huang, Suyun

Steeg, Patricia S.

机构：

[1] NCI, Mol Therapeut Program, Ctr Canc Res, Lab Mol Pharmacol,Womens Canc Sect, Bethesda, MD 20892 USA

[2] Univ Western Ontario, Dept Oncol, London, ON, Canada

[3] Univ Western Ontario, Dept Pathol, London, ON, Canada

[4] Univ Western Ontario, Dept Med Biophys, London, ON, Canada

[5] London Reg Canc Program, London, ON, Canada

[6] Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA USA

[7] Univ Texas, MD Anderson Canc Ctr, Dept Neurosurg, Houston, TX 77030 USA

来源：

CLINICAL CANCER RESEARCH | 2007年 / 13卷 / 06期

关键词：

D O I：

10.1158/1078-0432.CCR-06-2659

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Metastasis to the brain is prevalent in solid tumors and lymphomas, and is associated with shortened survival. The brain is regarded as a sanctuary site for metastatic tumor cells where they exist partially protected from drugs by the blood-tumor barrier. Model systems for brain metastasis have been developed and are now yielding mechanistic insights into the roles of angiogenesis, energy metabolism, the Her-2 and Stat3 signaling pathways, and dormancy. Specific, new approaches to combat brain metastatic disease are needed.

引用

页码：1656 / 1662

页数：7

共 74 条

[1] Targeting of melanoma brain metastases using engineered neural stem/progenitor cells [J].

Aboody, KS ;

Najbauer, J ;

Schmidt, NO ;

Yang, W ;

Wu, JK ;

Zhuge, Y ;

Przylecki, W ;

Carroll, R ;

Black, PM ;

Perides, G .

NEURO-ONCOLOGY, 2006, 8 (02) :119-126

[2] Halofuginone inhibits angiogenesis and growth in implanted metastatic rat brain tumor model - an MRI study [J].

Abramovitch, R ;

Itzik, A ;

Harel, H ;

Nagler, A ;

Vlodavsky, I ;

Siegal, T .

NEOPLASIA, 2004, 6 (05) :480-489

[3]

[Anonymous], 1978, ADV NEUROL

[4] Pathology-based substrate for target definition in radiosurgery of brain metastases [J].

Baumert, Brigitta G. ;

Rutten, Isabelle ;

Dehing-Oberije, Cary ;

Twijnstra, Albert ;

Dirx, Miranda J. M. ;

Debougnoux-Huppertz, Ria M. T. L. ;

Lambin, Philippe ;

Kubat, Bela .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2006, 66 (01) :187-194

[5] Central nervous system metastases in women who receive trastuzumab-based therapy for metastatic breast carcinoma [J].

Bendell, JC ;

Domchek, SM ;

Burstein, HJ ;

Harris, L ;

Younger, J ;

Kuter, I ;

Bunnell, C ;

Rue, M ;

Gelman, R ;

Winer, E .

CANCER, 2003, 97 (12) :2972-2977

[6] VEGF inhibitors in cancer therapy [J].

Cardones, AR ;

Bañez, LL .

CURRENT PHARMACEUTICAL DESIGN, 2006, 12 (03) :387-394

[7] Dissemination and growth of cancer cells in metastatic sites [J].

Chambers, AF ;

Groom, AC ;

MacDonald, IC .

NATURE REVIEWS CANCER, 2002, 2 (08) :563-572

[8]

CHEN E, IN PRESS CANC RES

[9] Incidence of cerebral metastases in patients treated with trastuzumab for metastatic breast cancer [J].

Clayton, AJ ;

Danson, S ;

Jolly, S ;

Ryder, WDJ ;

Burt, PA ;

Stewart, AL ;

Wilkinson, PM ;

Welch, RS ;

Magee, B ;

Wilson, G ;

Howell, A ;

Wardley, AM .

BRITISH JOURNAL OF CANCER, 2004, 91 (04) :639-643

[10] Rodent models of brain metastasis in melanoma [J].

Cranmer, LD ;

Trevor, KT ;

Bandlamuri, S ;

Hersh, EM .

MELANOMA RESEARCH, 2005, 15 (05) :325-356

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