The biology of metastasis to a sanctuary site

被引：114

作者：

Palmieri, Diane

Chambers, Ann F.

Felding-Habermann, Brunhilde

Huang, Suyun

Steeg, Patricia S.

机构：

[1] NCI, Mol Therapeut Program, Ctr Canc Res, Lab Mol Pharmacol,Womens Canc Sect, Bethesda, MD 20892 USA

[2] Univ Western Ontario, Dept Oncol, London, ON, Canada

[3] Univ Western Ontario, Dept Pathol, London, ON, Canada

[4] Univ Western Ontario, Dept Med Biophys, London, ON, Canada

[5] London Reg Canc Program, London, ON, Canada

[6] Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA USA

[7] Univ Texas, MD Anderson Canc Ctr, Dept Neurosurg, Houston, TX 77030 USA

来源：

CLINICAL CANCER RESEARCH | 2007年 / 13卷 / 06期

关键词：

D O I：

10.1158/1078-0432.CCR-06-2659

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Metastasis to the brain is prevalent in solid tumors and lymphomas, and is associated with shortened survival. The brain is regarded as a sanctuary site for metastatic tumor cells where they exist partially protected from drugs by the blood-tumor barrier. Model systems for brain metastasis have been developed and are now yielding mechanistic insights into the roles of angiogenesis, energy metabolism, the Her-2 and Stat3 signaling pathways, and dormancy. Specific, new approaches to combat brain metastatic disease are needed.

引用

收藏

页码：1656 / 1662

页数：7

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