P-aeruginosa quorum-sensing systems and virulence

被引：509

作者：

Smith, RS ^{[1
]}

Iglewski, BH ^{[1
]}

机构：

[1] Univ Rochester, Sch Med & Dent, Dept Microbiol & Immunol, Rochester, NY 14642 USA

来源：

CURRENT OPINION IN MICROBIOLOGY | 2003年 / 6卷 / 01期

关键词：

D O I：

10.1016/S1369-5274(03)00008-0

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Quorum sensing is an important mechanism for the regulation of genes in many Gram-negative and Gram-positive bacteria. In the opportunistic pathogen Pseudomonas aeruginosa, the absence of one or more components of the quorum-sensing system results in a significant reduction in virulence. Recent advances in the past year have demonstrated that the quorum-sensing signal molecule 30-C-12-HSL is also a potent stimulator of multiple eukaryotic cells and thus may alter the host response during P. aeruginosa infections. Therefore, via the regulation of multiple factors and the production of 30-C12-HSL, quorum-sensing systems have a significant effect on the virulence of the bacteria and also on how the host responds to P. aeruginosa infections.

引用

页码：56 / 60

页数：5

共 43 条

[1]

Alberts B., 2008, MOL BIOL CELL

[2] SYNTHESIS OF MULTIPLE EXOPRODUCTS IN PSEUDOMONAS-AERUGINOSA IS UNDER THE CONTROL OF RHLR-RHLI, ANOTHER SET OF REGULATORS IN STRAIN PAO1 WITH HOMOLOGY TO THE AUTOINDUCER-RESPONSIVE LUXR-LUXI FAMILY [J].

BRINT, JM ;

OHMAN, DE .

JOURNAL OF BACTERIOLOGY, 1995, 177 (24) :7155-7163

[3] Regulation of the xcp secretion pathway by multiple quorum-sensing modulons in Pseudomonas aeruginosa [J].

ChaponHerve, V ;

Akrim, M ;

Latifi, A ;

Williams, P ;

Lazdunski, A ;

Bally, M .

MOLECULAR MICROBIOLOGY, 1997, 24 (06) :1169-1178

[4] A novel and sensitive method for the quantification of N-3-oxoacyl homoserine lactones using gas chromatography-mass spectrometry:: application ito a model bacterial biofilm [J].

Charlton, TS ;

de Nys, R ;

Netting, A ;

Kumar, N ;

Hentzer, M ;

Givskov, M ;

Kjelleberg, S .

ENVIRONMENTAL MICROBIOLOGY, 2000, 2 (05) :530-541

[5] Pseudomonas aeruginosa virulence analyzed in a Dictyostelium discoideum host system [J].

Cosson, P ;

Zulianello, L ;

Join-Lambert, O ;

Faurisson, F ;

Gebbie, L ;

Benghezal, M ;

van Delden, C ;

Curty, LK ;

Köhler, T .

JOURNAL OF BACTERIOLOGY, 2002, 184 (11) :3027-3033

[6] Bacterial quorum sensing in pathogenic relationships [J].

de Kievit, TR ;

Iglewski, BH .

INFECTION AND IMMUNITY, 2000, 68 (09) :4839-4849

[7]

DEZATEUX C, 2000, COCHRANE DB SYST REV, V2

[8] DIVERSE PSEUDOMONAS-AERUGINOSA GENE-PRODUCTS STIMULATE RESPIRATORY EPITHELIAL-CELLS TO PRODUCE INTERLEUKIN-8 [J].

DIMANGO, E ;

ZAR, HJ ;

BRYAN, R ;

PRINCE, A .

JOURNAL OF CLINICAL INVESTIGATION, 1995, 96 (05) :2204-2210

[9] Pseudomonas aeruginosa quorum-sensing systems may control virulence factor expression in the lungs of patients with cystic fibrosis [J].

Erickson, DL ;

Endersby, R ;

Kirkham, A ;

Stuber, K ;

Vollman, DD ;

Rabin, HR ;

Mitchell, I ;

Storey, DG .

INFECTION AND IMMUNITY, 2002, 70 (04) :1783-1790

[10] LASR OF PSEUDOMONAS-AERUGINOSA IS A TRANSCRIPTIONAL ACTIVATOR OF THE ALKALINE PROTEASE GENE (APR) AND AN ENHANCER OF EXOTOXIN-A EXPRESSION [J].

GAMBELLO, MJ ;

KAYE, S ;

IGLEWSKI, BH .

INFECTION AND IMMUNITY, 1993, 61 (04) :1180-1184

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