P-aeruginosa quorum-sensing systems and virulence

被引：509

作者：

Smith, RS ^{[1
]}

Iglewski, BH ^{[1
]}

机构：

[1] Univ Rochester, Sch Med & Dent, Dept Microbiol & Immunol, Rochester, NY 14642 USA

来源：

CURRENT OPINION IN MICROBIOLOGY | 2003年 / 6卷 / 01期

关键词：

D O I：

10.1016/S1369-5274(03)00008-0

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Quorum sensing is an important mechanism for the regulation of genes in many Gram-negative and Gram-positive bacteria. In the opportunistic pathogen Pseudomonas aeruginosa, the absence of one or more components of the quorum-sensing system results in a significant reduction in virulence. Recent advances in the past year have demonstrated that the quorum-sensing signal molecule 30-C-12-HSL is also a potent stimulator of multiple eukaryotic cells and thus may alter the host response during P. aeruginosa infections. Therefore, via the regulation of multiple factors and the production of 30-C12-HSL, quorum-sensing systems have a significant effect on the virulence of the bacteria and also on how the host responds to P. aeruginosa infections.

引用

页码：56 / 60

页数：5

共 43 条

[21] Pseudomonas aeruginosa cell-to-cell signaling is required for virulence in a model of acute pulmonary infection [J].

Pearson, JP ;

Feldman, M ;

Iglewski, BH ;

Prince, A .

INFECTION AND IMMUNITY, 2000, 68 (07) :4331-4334

[22] Transcriptional control of the hydrogen cyanide biosynthetic genes hcnABC by the anaerobic regulator ANR and the quorum-sensing regulators LasR and RhlR in Pseudomonas aeruginosa [J].

Pessi, G ;

Haas, D .

JOURNAL OF BACTERIOLOGY, 2000, 182 (24) :6940-6949

[23] COMMON VIRULENCE FACTORS FOR BACTERIAL PATHOGENICITY IN PLANTS AND ANIMALS [J].

RAHME, LG ;

STEVENS, EJ ;

WOLFORT, SF ;

SHAO, J ;

TOMPKINS, RG ;

AUSUBEL, FM .

SCIENCE, 1995, 268 (5219) :1899-1902

[24] How Delisea pulchra furanones affect quorum sensing and swarming motility in Serratia liquefaciens MG1 [J].

Rasmussen, TB ;

Manefield, M ;

Andersen, JB ;

Eberl, L ;

Anthoni, U ;

Christophersen, C ;

Steinberg, P ;

Kjelleberg, S ;

Givskov, M .

MICROBIOLOGY-UK, 2000, 146 :3237-3244

[25] Contribution of the Regulatory Gene lasR to the pathogenesis of Pseudomonas aeruginosa infection of burned mice [J].

Rumbaugh, KP ;

Griswold, JA ;

Hamood, AN .

JOURNAL OF BURN CARE & REHABILITATION, 1999, 20 (01) :42-49

[26] Contribution of quorum sensing to the virulence of Pseudomonas aeruginosa in burn wound infections [J].

Rumbaugh, KP ;

Griswold, JA ;

Iglewski, BH ;

Hamood, AN .

INFECTION AND IMMUNITY, 1999, 67 (11) :5854-5862

[27] Pseudomonas aeruginosa quorum-sensing signal molecule N-(3-oxododecanoyl)-L-homoserine lactone inhibits expression of P2Y receptors in cystic fibrosis tracheal gland cells [J].

Saleh, A ;

Figarella, C ;

Kammouni, W ;

Marchand-Pinatel, S ;

Lazdunski, A ;

Tubul, A ;

Brun, P ;

Merten, MD .

INFECTION AND IMMUNITY, 1999, 67 (10) :5076-5082

[28] ACTIVATION OF THE PSEUDOMONAS-AERUGINOSA LASI GENE BY LASR AND THE PSEUDOMONAS AUTOINDUCER PAI - AN AUTOINDUCTION REGULATORY HIERARCHY [J].

SEED, PC ;

PASSADOR, L ;

IGLEWSKI, BH .

JOURNAL OF BACTERIOLOGY, 1995, 177 (03) :654-659

[29] Cyclooxygenase-2 inhibitor NS-398 improves survival and restores leukocyte counts in burn infection [J].

Shoup, M ;

He, LK ;

Liu, H ;

Shankar, R ;

Gamelli, R .

JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 1998, 45 (02) :215-220

[30] Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms [J].

Singh, PK ;

Schaefer, AL ;

Parsek, MR ;

Moninger, TO ;

Welsh, MJ ;

Greenberg, EP .

NATURE, 2000, 407 (6805) :762-764

← 1 2 3 4 5 →