Phosphorylation of the pro-apoptotic protein Bim in lymphocytes is associated with protection from apoptosis

被引：43

作者：

Seward, RJ

von Haller, PD

Aebersold, R

Huber, BT

机构：

[1] Tufts Univ, Sch Med, Dept Pathol, Boston, MA 02111 USA

[2] Inst Syst Biol, Seattle, WA 98105 USA

来源：

MOLECULAR IMMUNOLOGY | 2003年 / 39卷 / 16期

关键词：

Bcl-2; family; interleukin; 2; apoptosis; thymocytes; HT-2; cells; B cell lymphoma;

D O I：

10.1016/S0161-5890(03)00047-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bim is a pro-apoptotic member of the Bcl-2 protein family. Bim has three isoforms, EL, L, and S, of which the EL form is the least cytotoxic. We show here that Bim is serine phosphorylated in lymphocytes, predominantly on the EL form. Withdrawal of IL-2 from IL-2-dependent T lymphocytes or culture of thymocytes leads to reduced Bim phosphorylation and apoptosis induction. This decrease in Bim phosphorylation occurs when most cells in culture are still viable, indicating that reduction of Bim phosphorylation may be an early event in apoptosis signaling of lymphocytes. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：983 / 993

页数：11

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