Two enabling architectures for DNA-templated organic synthesis

被引：82

作者：

Gartner, ZJ ^{[1
]}

Grubina, R ^{[1
]}

Calderone, CT ^{[1
]}

Liu, DR ^{[1
]}

机构：

[1] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 12期

关键词：

bioorganic chemistry; combinatorial chemistry; DNA; template synthesis;

D O I：

10.1002/anie.200390351

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Reactivity can be rationally manipulated in DNA-templated synthesis by altering the design of template architectures: a) The omega (Ω) architecture enables DNA-templated reactions to be encoded by bases distal from the reactive end of the template, regardless of the distance dependence of the reaction. b) The T architecture enables two DNA-templated reactions to take place on a single template in one solution, as illustrated.

引用

页码：1370 / 1375

页数：6

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