Diastereoselective titanium-mediated construction of cis-2,3-ring annelated 1-(2′-chloroethyl)cyclopropanols

被引：20

作者：

Lecornué, F ^{[1
]}

Ollivier, J ^{[1
]}

机构：

[1] Univ Paris 11, Inst Chim Mol & Mat Orsay, UMR 8615, Lab Carbocycles, F-91405 Orsay, France

来源：

CHEMICAL COMMUNICATIONS | 2003年 / 05期

关键词：

D O I：

10.1039/b211642a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Titanium(IV)-mediated cyclopropanation induced by reaction of cycloalkylmagnesium bromides 1a-e in the presence of titanium tetraisopropoxide with ethyl beta-chloropropionate 2 yielded cis-fused 1-(2'-chloroethyl) cyclopropanols 3b-e with diastereoselectivity highly depending on the ring size. Unexpected rearrangement products 5d, e were isolated in some cases.

引用

页码：584 / 585

页数：2

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