Dobutamine administration exacerbates postischaemic myocardial dysfunction in isolated rat hearts: an effect reversed by thyroxine pretreatment

被引:21
作者
Pantos, C
Mourouzis, I
Tzeis, S
Moraitis, P
Malliopoulou, V
Cokkinos, DD
Carageorgiou, H
Varonos, D
Cokkinos, D
机构
[1] Univ Athens, Dept Pharmacol, Athens 11527, Greece
[2] Onassis Cardiac Surg Ctr, Cardiol Dept 1, Athens 17674, Greece
关键词
inotrope; ischaemia; dobutamine; thyroxine; heart; rat;
D O I
10.1016/S0014-2999(02)02927-8
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The present study has investigated the effects of dobutamine on postischaemic dysfunction in the setting of global ischaemia and reperfusion in a model of isolated heart preparation. Isolated rat hearts were subjected to 20 min of zero-flow global ischaemia followed by 45 min of reperfusion. Dobutamine administration (10 mug/kg/min) during the reperfusion period resulted in deterioration of functional recovery, which was abolished by propranolol administration. Long-term thyroxine pretreatment (12.5 mug 100 g(-1) body weight, b.i.d., s.c., for 2 weeks) reversed the detrimental effect of dobutamine and increased postischaemic recovery of function. We conclude that the combination of thyroxine pretreatment and dobutamine administration could potentially be a new therapeutic strategy to improve postischaemic dysfunction particularly in clinical settings such as cardiopulmonary bypass and/or myocardial infarction. (C) 2003 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:155 / 161
页数:7
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