Enantioselective synthesis of trifluoromethyl-substituted cyclopropanes

被引：110

作者：

Denton, Justin R. ^{[1
]}

Sukumaran, Dinesh ^{[1
]}

Davies, Huw M. L. ^{[1
]}

机构：

[1] SUNY Buffalo, Dept Chem, Buffalo, NY 14260 USA

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 14期

关键词：

D O I：

10.1021/ol070714f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of 1-aryl-2,2,2-trifluorodiazoethanes with alkenes, catalyzed by the adamantylglycine-derived dirhodium complex Rh-2(R-PTAD)(4), generates trifluoromethyl-substituted cyclopropanes with high diastereoselectivity (> 94%) and enantioselectivity (88-> 98%).

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页码：2625 / 2628

页数：4

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