When more is better

被引：4

作者：

Petrini, JHJ ^{[1
]}

机构：

[1] Univ Wisconsin, Sch Med, Genet Lab, Madison, WI 53706 USA

来源：

NATURE GENETICS | 2000年 / 26卷 / 03期

关键词：

D O I：

10.1038/81529

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Nucleotide excision repair (NER) is a highly conserved multi-step process. Congenital NER defects are clinically complex, at least in part because components of the NER machinery also function in the basal transcription factor, TFIIH. A new study demonstrates that reduction in the amount, rather than the inherent activity, of TFIIH is the underlying cause of one such congenital NER defect, underscoring the link between transcription and NER-associated disease.

引用

页码：257 / 258

页数：2

共 9 条

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