Aging and immunoglobulin isotype patterns in oral tolerance

被引：20

作者：

Faria, AMC ^{[1
]}

Ficker, SM ^{[1
]}

Speziali, E ^{[1
]}

Menezes, JS ^{[1
]}

Stransky, B ^{[1
]}

Verdolin, BA ^{[1
]}

Lahmann, WM ^{[1
]}

Rodrigues, VS ^{[1
]}

Vaz, NM ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Bioquim & Imunol, BR-31270901 Belo Horizonte, MG, Brazil

来源：

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH | 1998年 / 31卷 / 01期

关键词：

oral tolerance; aging; isotypes; gut; mucosa;

D O I：

10.1590/S0100-879X1998000100005

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In the present review we address oral tolerance as an important biological phenomenon and discuss how it is affected by aging. Other factors such as frequency of feeding and previous digestion of the antigen also seem to influence the establishment of oral tolerance. We also analyze immunoglobulin isotypes of specific antibodies formed by tolerant and immunized animals of different ages submitted to different conditions of oral antigen administration. Isotypic patterns were studied as a parameter for assessing the pathways of B and T cell interactions leading to antibody production.

引用

页码：35 / 48

页数：14

共 100 条

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[52] THE NATURAL IMMUNE-RESPONSE TO INHALED SOLUBLE-PROTEIN ANTIGENS INVOLVES MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) CLASS-I RESTRICTED CD8+ T-CELL MEDIATED BUT MHC CLASS-II RESTRICTED CD4+ T-CELL-DEPENDENT IMMUNE DEVIATION RESULTING IN SELECTIVE SUPPRESSION OF IMMUNOGLOBULIN-E PRODUCTION [J].