A critical analysis of evidence for using sham surgery in Parkinson's disease: implications for public health

被引：6

作者：

Polgar, Stephen ^{[1
]}

Ng, Joanna ^{[1
]}

机构：

[1] La Trobe Univ, Fac Hlth Sci, Sch Publ Hlth, Bundoora, Vic 3086, Australia

来源：

AUSTRALIAN AND NEW ZEALAND JOURNAL OF PUBLIC HEALTH | 2007年 / 31卷 / 03期

关键词：

cellular therapies; sham surgery; public health; placebo-controlled randomised controlled trials; evidence-based medicine;

D O I：

10.1111/j.1467-842X.2007.00060.x

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Sham surgery was introduced as a means for improving the methodological quality of surgical research and evaluation. The development of cellular-based surgical therapies for the treatment of Parkinson's disease provides an opportunity to carefully analyse the alleged methodological benefits of sham surgery. However, detailed analysis of the evidence does not support these hypothesised advantages. In this paper, we argue that sham surgery is a public health concern as vulnerable individuals are exposed to unnecessary and costly surgical procedures that have no benefits for ensuring rigorous health research.

引用

页码：270 / 274

页数：5

共 38 条

[1] Sham surgery controls are mitigated trolleys [J].

Albin, RL .

JOURNAL OF MEDICAL ETHICS, 2005, 31 (03) :149-152

[2] Sham surgery controls: intracerebral grafting of fetal tissue for Parkinson's disease and proposed criteria for use of sham surgery controls [J].

Albin, RL .

JOURNAL OF MEDICAL ETHICS, 2002, 28 (05) :324-327

[3] The revised CONSORT statement for reporting randomized trials: Explanation and elaboration [J].

Altman, DG ;

Schulz, KF ;

Moher, D ;

Egger, M ;

Davidoff, F ;

Elbourne, D ;

Gotzsche, PC ;

Lang, T .

ANNALS OF INTERNAL MEDICINE, 2001, 134 (08) :663-694

[4]

BIRRELL B, 2003, OUTLOOK SURG SERVICE, P28

[5] Clinical neurotransplantation: Core assessment protocol rather than sham surgery as control [J].

Boer, GJ ;

Widner, H .

BRAIN RESEARCH BULLETIN, 2002, 58 (06) :547-553

[6]

CESARO P, 2005, NEURORX, V1, P492

[7] Long-term outcome of unilaterally transplanted Parkinsonian patients .1. Clinical approach [J].

Defer, GL ;

Geny, C ;

Ricolfi, F ;

Fenelon, G ;

Monfort, JC ;

Remy, P ;

Villafane, G ;

Jeny, R ;

Samson, Y ;

Keravel, Y ;

Gaston, A ;

Degos, JD ;

Peschanski, M ;

Cesaro, P ;

Nguyen, JP .

BRAIN, 1996, 119 :41-50

[8] Sham neurosurgery in patients with Parkinson's disease: is it morally acceptable? [J].

Dekkers, W ;

Boer, G .

JOURNAL OF MEDICAL ETHICS, 2001, 27 (03) :151-156

[9] What is the risk of sham surgery in Parkinson disease clinical trials? A review of published reports [J].

Frank, S ;

Kieburtz, K ;

Holloway, R ;

Kim, SYH .

NEUROLOGY, 2005, 65 (07) :1101-1103

[10] Transplantation of embryonic dopamine neurons for severe Parkinson's disease. [J].

Freed, CR ;

Greene, PE ;

Breeze, RE ;

Tsai, WY ;

DuMouchel, W ;

Kao, R ;

Dillon, S ;

Winfield, H ;

Culver, S ;

Trojanowski, JQ ;

Eidelberg, D ;

Fahn, S .

NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (10) :710-719

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