Is parathyroid hormone a therapeutic option for osteoporosis? A review of the clinical evidence

被引:77
作者
Cosman, F [1 ]
Lindsay, R
机构
[1] Helen Hayes Hosp, Reg Bone Ctr, Clin Res Ctr, W Haverstraw, NY 10993 USA
[2] Columbia Presbyterian Med Ctr, Dept Med, New York, NY 10032 USA
关键词
hormone replacement therapy; estrogen; salmon calcitonin; alendronate; bone turnover;
D O I
10.1007/s002239900464
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Most of the data on the anabolic effect of PTH have been obtained with hPTH(1-34). Studies have shown a marked increment in spinal bone mass. Most recently we have shown that PTH and estrogen can be given together where there is increased total bone mineral and no loss of bone at any skeletal site. We have also shown the first reduction in vertebral deformity incidence due to PTH treatment.
引用
收藏
页码:475 / 480
页数:6
相关论文
共 90 条
  • [61] PARSONS J A, 1981, Biochemical Society Transactions, V9, P383
  • [62] PARATHYROID-HORMONE INCREASES THE CONCENTRATION OF INSULIN-LIKE GROWTH-FACTOR-I AND TRANSFORMING GROWTH-FACTOR-BETA-1 IN RAT BONE
    PFEILSCHIFTER, J
    LAUKHUF, F
    MULLERBECKMANN, B
    BLUM, WF
    PFISTER, T
    ZIEGLER, R
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1995, 96 (02) : 767 - 774
  • [63] EFFECTS OF 2 TREATMENT REGIMES WITH SYNTHETIC HUMAN PARATHYROID-HORMONE FRAGMENT ON BONE-FORMATION AND THE TISSUE BALANCE OF TRABECULAR BONE IN GREYHOUNDS
    PODBESEK, R
    EDOUARD, C
    MEUNIER, PJ
    PARSONS, JA
    REEVE, J
    STEVENSON, RW
    ZANELLI, JM
    [J]. ENDOCRINOLOGY, 1983, 112 (03) : 1000 - 1006
  • [64] Pollock JH, 1996, J BONE MINER RES, V11, P754
  • [65] REEVE J, 1976, LANCET, V1, P1035
  • [66] ANABOLIC EFFECT OF HUMAN PARATHYROID-HORMONE FRAGMENT ON TRABECULAR BONE IN INVOLUTIONAL OSTEOPOROSIS - A MULTICENTER TRIAL
    REEVE, J
    MEUNIER, PJ
    PARSONS, JA
    BERNAT, M
    BIJVOET, OLM
    COURPRON, P
    EDOUARD, C
    KLENERMAN, L
    NEER, RM
    RENIER, JC
    SLOVIK, D
    VISMANS, FJFE
    POTTS, JT
    [J]. BMJ-BRITISH MEDICAL JOURNAL, 1980, 280 (6228): : 1340 - 1344
  • [67] PERIODIC COURSES OF HUMAN 1-34-PARATHYROID PEPTIDE ALTERNATING WITH CALCITRIOL PARADOXICALLY REDUCE BONE REMODELING IN SPINAL OSTEOPOROSIS
    REEVE, J
    ARLOT, M
    PRICE, TR
    EDOUARD, C
    HESP, R
    HULME, P
    ASHBY, JP
    ZANELLI, JM
    GREEN, JR
    TELLEZ, M
    KATZ, D
    SPINKS, TJ
    MEUNIER, PJ
    [J]. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 1987, 17 (05) : 421 - 428
  • [68] HUMAN PARATHYROID PEPTIDE TREATMENT OF VERTEBRAL OSTEOPOROSIS
    REEVE, J
    ARLOT, ME
    BRADBEER, JN
    HESP, R
    MCALLY, E
    MEUNIER, PJ
    ZANELLI, JM
    [J]. OSTEOPOROSIS INTERNATIONAL, 1993, 3 : S199 - S203
  • [69] CA-47 KINETIC MEASUREMENTS OF BONE TURNOVER COMPARED TO BONE HISTOMORPHOMETRY IN OSTEOPOROSIS - THE INFLUENCE OF HUMAN PARATHYROID FRAGMENT (HPTH 1-34) THERAPY
    REEVE, J
    ARLOT, M
    BERNAT, M
    CHARHON, S
    EDOUARD, C
    SLOVIK, D
    VISMANS, FJFE
    MEUNIER, PJ
    [J]. METABOLIC BONE DISEASE & RELATED RESEARCH, 1981, 3 (01): : 23 - 30
  • [70] REEVE J, 1976, CALC TISS RES, V21, P469