The role of melanocortin receptors in sexual behavior in female rats

被引：30

作者：

Cragnolini, A

Scimonelli, T

Celis, ME

Schiöth, HB

机构：

[1] Uppsala Univ, Dept Neurosci, Uppsala, Sweden

[2] Melacure Therapeut AB, Uppsala, Sweden

[3] Univ Nacl Cordoba, Fac Ciencias Quim, Dept Farmacol, Lab Fisiol, RA-5000 Cordoba, Argentina

来源：

NEUROPEPTIDES | 2000年 / 34卷 / 3-4期

关键词：

D O I：

10.1054/npep.2000.0815

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Earlier data have indicated that a-MSH may play a role for sexual behavior in rats. In this study we investigated the effects of MSH peptides on sexual receptivity in Qvariectomized-adrenalectomized female rats, pretreated with benzoate of estradiol, in presence of vigorous male rats. The results show that alpha -MSH significantly increases lordosis behavior in female rats after injections into the ventromedial nucleus. Interestingly, we have for the first time shown that gamma -MSH also causes significant increase in lordosis in female rats. Furthermore, we show that HS014, an antagonist for the central MC receptors, in dose dependent manner blocks the effect of alpha -MSH on lordosis. The results indicate that the effects of MSH peptides on female sexual behaviour are mediated through a specific MC receptor, which could be the MC3 receptor. (C) 2000 Harcourt Publishers Ltd.

引用

页码：211 / 215

页数：5

共 27 条

[1] Neuropeptides and sexual behaviour [J].