Gremlins, glomeruli and diabetic nephropathy

被引：25

作者：

Lappin, DWP

Hensey, C

McMahon, R

Godson, C

Brady, HR

机构：

[1] Mater Misericordiae Hosp, Dept Med & Therapeut, Dublin 7, Ireland

[2] Univ Coll Dublin, Conway Inst Biomol & Biomed Res, Dept Med & Therapeut, Dublin 2, Ireland

[3] Univ Coll Dublin, Conway Inst Biomol & Biomed Res, Dept Pharmacol, Dublin 2, Ireland

来源：

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION | 2000年 / 9卷 / 05期

关键词：

D O I：

10.1097/00041552-200009000-00002

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

There have been major advances in our understanding of the pathogenetic mechanisms of diabetic nephropathy in recent years. Of particular interest is the emerging paradigm of the role that developmentally important genes may play in this process, representing recapitulation of the ontogenic process. This review examines the potential pathophysiological involvement of one such developmental gene gremlin in diabetic nephropathy, Curr Opin Nephrol Hypertens 9:469-472. (C) 2000 Lippincott Williams & Wilkins.

引用

页码：469 / 472

页数：4

共 35 条

[1] Control of vertebrate limb outgrowth by the proximal factor Meis2 and distal antagonism of BMPs by Gremlin [J].