The silence of the genes

被引：83

作者：

Plasterk, RHA ^{[1
]}

Ketting, RF ^{[1
]}

机构：

[1] Hubrecht Lab, NL-3584 CT Utrecht, Netherlands

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2000年 / 10卷 / 05期

关键词：

D O I：

10.1016/S0959-437X(00)00128-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

About two years ago, it was recognized that introduction of double-stranded RNA (dsRNA) had a potent effect on gene expression, in particular on mRNA stability. Since then, this process has been found to occur in many different organisms, and to bear a strong resemblance to a previously recognized process in plants, called cosuppression. Both genetic and biochemical studies have started to unravel the mysteries of RNA interference: genes involved in this process are being identified and in vitro studies are giving the first hints of what is happening to both the dsRNA and the affected mRNA molecules after the introduction of the dsRNA.

引用

收藏

页码：562 / 567

页数：6

相关论文

共 54 条

[1] A viral suppressor of gene silencing in plants [J].

Anandalakshmi, R ;

Pruss, GJ ;

Ge, X ;

Marathe, R ;

Mallory, AC ;

Smith, TH ;

Vance, VB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (22) :13079-13084

[2] Double-stranded RNA as a template for gene silencing [J].

Bass, BL .

CELL, 2000, 101 (03) :235-238

[3] Cosuppression comes to the animals [J].

Bingham, PM .

CELL, 1997, 90 (03) :385-387

[4]

Bosher JM, 1999, GENETICS, V153, P1245

[5] Transcription - Gene silencing in worms and fungi [J].

Catalanotto, C ;

Azzalin, G ;

Macino, G ;

Cogoni, C .

NATURE, 2000, 404 (6775) :245-245

[6] Specific and heritable genetic interference by double-stranded RNA in Arabidopsis thaliana [J].

Chuang, CF ;

Meyerowitz, EM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (09) :4985-4990

[7] Posttranscriptional gene silencing in Neurospora by a RecQ DNA helicase [J].

Cogoni, C ;

Macino, G .

SCIENCE, 1999, 286 (5448) :2342-2344

[8] Isolation of quelling-defective (qde) mutants impaired in posttranscriptional transgene-induced gene silencing in Neurospora crassa [J].

Cogoni, C ;

Macino, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (19) :10233-10238

[9] Gene silencing in Neurospora crassa requires a protein homologous to RNA-dependent RNA polymerase [J].

Cogoni, C ;

Macino, G .

NATURE, 1999, 399 (6732) :166-169

[10] Transgene silencing of the al-1 gene in vegetative cells of Neurospora is mediated by a cytoplasmic effector and does not depend on DNA-DNA interactions or DNA methylation [J].

Cogoni, C ;

Irelan, JT ;

Schumacher, M ;

Schmidhauser, TJ ;

Selker, EU ;

Macino, G .

EMBO JOURNAL, 1996, 15 (12) :3153-3163

← 1 2 3 4 5 6 →