Recombination Analysis Tool (RAT): a program for the high-throughput detection of recombination

被引：90

作者：

Etherington, GJ

Dicks, J

Roberts, IN

机构：

[1] Inst Food Res, Dept Food Safety Sci, Norwich NR4 7HA, Norfolk, England

[2] John Innes Ctr Plant Sci Res, Computat Biol Grp, Norwich NR4 7HA, Norfolk, England

来源：

BIOINFORMATICS | 2005年 / 21卷 / 03期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1093/bioinformatics/bth500

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Motivation: Recombination can be a prevailing drive in shaping genome evolution. RAT (Recombination Analysis Tool) is a Java-based tool for investigating recombination events in any number of aligned sequences (protein or DNA) of any length (short viral sequences to full genomes). It is an uncomplicated and intuitive application and allows the user to view only the regions of sequence alignments they are interested in. Results: RAT was applied to viral sequences. Its utility was demonstrated through the detection of a known recombinant of HIV and a detailed analysis of Noroviruses, the most common cause of viral gastroenteritis in humans.

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页码：278 / 281

页数：4

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