Erythropoietin protects cultured cortical neurons, but not astroglia, from hypoxia and AMPA toxicity

被引：106

作者：

Sinor, AD ^{[1
]}

Greenberg, DA ^{[1
]}

机构：

[1] Buck Ctr Res Aging, Novato, CA 94948 USA

来源：

NEUROSCIENCE LETTERS | 2000年 / 290卷 / 03期

关键词：

erythropoietin; AMPA; hypoxia; cell culture; ischemia;

D O I：

10.1016/S0304-3940(00)01361-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In addition to its better-known hemopoietic action, erythropoietin (Epo) has neurotrophic properties and neuroprotective effects in some models of hypoxic-ischemic injury. To define further the cellular mechanisms underlying neuroprotection by Epo, we studied the effects of Epo on hypoxia with glucose deprivation in cultured rat cortical neurons and astroglia and on exposure to excitotoxins in cultured rat cortical neurons. Epo (30 pM) reduced neuronal, but not astroglial, cell death from hypoxia with glucose deprivation, and also attenuated the neurotoxic effect of (+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), but not other excitotoxins. Epo appears to protect against cerebral ischemia through a direct effect on neurons that may be mediated in part by AMPA receptors. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：213 / 215

页数：3

共 26 条

[1] Protein kinase B (c-Akt), phosphatidylinositol 3-kinase, and STAT5 are activated by erythropoietin (EPO) in HCD57 erythroid cells but are constitutively active in an EPO-independent, apoptosis-resistant subclone (HCD57-SREI cells) [J].