Scedosporium prolificans brain abscess in a patient with chronic granulomatous disease: Successful combination therapy with vorieonazole and terbinafine

被引：70

作者：

Bhat, Sunil V.

Paterson, David L.

Rinaldi, Michael G.

Veldkamp, Peter J.

机构：

[1] Univ Pittsburgh, Med Ctr, Div Infect Dis, Pittsburgh, PA 15213 USA

[2] Univ Texas, Hlth Sci Ctr, Dept Pathol, San Antonio, TX 78284 USA

来源：

SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES | 2007年 / 39卷 / 01期

关键词：

D O I：

10.1080/00365540600786564

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

A patient with chronic granulomatous disease developed brain abscesses with Scedosporium prolificans. In vitro susceptibility revealed a synergistic effect of terbinafine and voriconazole. He received therapy with both these antifungals which resulted in disappearance of the brain abscesses. This is the first reported cure of a CNS S. prolificans infection in an immunocompromised host.

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页码：87 / 90

页数：4

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