Why do we lack an effective vaccine against herpes simplex virus infections?

被引:30
作者
Deshpande, SP [1 ]
Kumaraguru, U [1 ]
Rouse, BT [1 ]
机构
[1] Univ Tennessee, Dept Microbiol, Knoxville, TN 37996 USA
关键词
herpes simplex virus; immune response; vaccines;
D O I
10.1016/S1286-4579(00)00339-7
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
This review discusses the possible causes for the lack of an effective antiherpes vaccine. Future prospects of vaccines based on the current knowledge of immune responses to herpes viruses are discussed. It is argued that vaccines capable of expanding CD8 T-cell memory responses should be the focus of future anti-herpes simplex virus research. (C) 2000 Editions scientifiques et medicales Elsevier SAS.
引用
收藏
页码:973 / 978
页数:6
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