Molecular mechanisms and Th1/Th2 pathways in corticosteroid regulation of cytokine production

被引：83

作者：

Kovalovsky, D

Refojo, D

Holsboer, F

Arzt, E

机构：

[1] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Biol, Lab Fisiol & Biol Mol, RA-1428 Buenos Aires, DF, Argentina

[2] Consejo Nacl Invest Cient & Tecn, RA-1033 Buenos Aires, DF, Argentina

[3] Max Planck Inst Psychiat, D-80804 Munich, Germany

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2000年 / 109卷 / 01期

关键词：

IL-1; IL-1ra; glucocorticoids; Th1; Th2; cytokines;

D O I：

10.1016/S0165-5728(00)00298-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We focus on how the IL-I system, T-halper1 (Th1) or Th2 cytokines and glucocorticoids, converge to give a unified physiological response. Glucocorticoids inhibit IL-I and IL-1 receptor antagonist (IL-1ra) expression, Th1 cytokines stimulate both and Th2 cytokines stimulate IL-1ra and inhibit IL-1. Thus, during the Th1 response there is a window for IL-1 inflammatory activity, absent during the Th2 response. We also study the interactions among glucocorticoid and cytokine transcriptional activity. Glucocorticoids inhibit cytokine induced transcription factors (NFkB, AP1) and cytokines enhance glucocorticoid receptor (GR) transcriptional activity, thus reciprocally fine tuning immunological control mechanisms. (C) 2000 Elsevier Science BN. All rights reserved.

引用

页码：23 / 29

页数：7

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