Direct sequencing of the human microbiome readily reveals community differences

被引：120

作者：

Kuczynski, Justin ^{[2
]}

Costello, Elizabeth K. ^{[6
]}

Nemergut, Diana R. ^{[3
]}

Zaneveld, Jesse ^{[2
]}

Lauber, Christian L. ^{[4
]}

Knights, Dan ^{[5
]}

Koren, Omry ^{[7
]}

Fierer, Noah ^{[4
]}

Kelley, Scott T. ^{[8
]}

Ley, Ruth E. ^{[7
]}

Gordon, Jeffrey I. ^{[9
]}

Knight, Rob ^{[1
,10
]}

机构：

[1] Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA

[2] Univ Colorado, Dept Mol Cellular & Dev Biol, Boulder, CO 80309 USA

[3] Univ Colorado, INSTAAR, Boulder, CO 80309 USA

[4] Univ Colorado, CIRES, Boulder, CO 80309 USA

[5] Univ Colorado, Dept Comp Sci, Boulder, CO 80309 USA

[6] Stanford Univ, Dept Microbiol & Immunol, Stanford, CA 94305 USA

[7] Cornell Univ, Dept Microbiol, Ithaca, NY 14853 USA

[8] San Diego State Univ, Dept Biol, San Diego, CA 92182 USA

[9] Washington Univ, Sch Med, Ctr Genome Sci, St Louis, MO 63108 USA

[10] Univ Colorado, Howard Hughes Med Inst, Boulder, CO 80309 USA

来源：

GENOME BIOLOGY | 2010年 / 11卷 / 05期

关键词：

GUT MICROBIOTA; MOLECULAR ANALYSIS; CROHNS-DISEASE; DIVERSITY; EVOLUTION; PATTERNS;

D O I：

10.1186/gb-2010-11-5-210

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Culture-independent studies of human microbiota by direct genomic sequencing reveal quite distinct differences among communities, indicating that improved sequencing capacity can be most wisely utilized to study more samples, rather than more sequences per sample.

引用

页数：9

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