NF-κB transcription factors:: critical regulators of hematopoiesis and neuronal survival

被引:109
作者
Denk, A [1 ]
Wirth, T [1 ]
Baumann, B [1 ]
机构
[1] Univ Ulm, Dept Physiol Chem, D-89081 Ulm, Germany
关键词
NF-kappa B; hematopoiesis; apoptosis; neuronal survival; signal transduction;
D O I
10.1016/S1359-6101(00)00009-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The Rel/NF-kappa B family of transcription factors has been implicated in the regulation of genes involved in immune and inflammatory responses. and of processes such as cell survival, apoptosis, development, differentiation, cell growth and neoplastic transformation. In this report we will summarize recent findings which highlight critical roles of NF-KB in different processes in hematopoietic and neuronal cells. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:303 / 320
页数:18
相关论文
共 219 条
  • [81] Nuclear translocation of NF-kappa B is increased in dopaminergic neurons of patients with Parkinson disease
    Hunot, S
    Brugg, B
    Ricard, D
    Michel, PP
    Muriel, MP
    Ruberg, M
    Faucheux, BA
    Agid, Y
    Hirsch, EC
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (14) : 7531 - 7536
  • [82] The transcription factor interferon regulatory factor 1 is expressed after cerebral ischemia and contributes to ischemic brain injury
    Iadecola, C
    Salkowski, CA
    Zhang, FY
    Aber, T
    Nagayama, M
    Vogel, SN
    Ross, ME
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (04) : 719 - 727
  • [83] Iciek LA, 1997, J IMMUNOL, V158, P4769
  • [84] Isenmann S, 1998, BRAIN PATHOL, V8, P49
  • [85] TRANSCRIPTION FACTORS IN MOUSE FETAL THYMUS DEVELOPMENT
    IVANOV, V
    CEREDIG, R
    [J]. INTERNATIONAL IMMUNOLOGY, 1992, 4 (07) : 729 - 737
  • [86] Regulation of Fas-dependent activation-induced T cell apoptosis by cAMP signaling: A potential role for transcription factor NF-kappa B
    Ivanov, VN
    Lee, RK
    Podack, ER
    Malek, TR
    [J]. ONCOGENE, 1997, 14 (20) : 2455 - 2464
  • [87] JAMIESON C, 1991, J IMMUNOL, V147, P416
  • [88] CORRECTION OF RADIATION SENSITIVITY IN ATAXIA-TELANGIECTASIA CELLS BY A TRUNCATED I-KAPPA-B-ALPHA
    JUNG, M
    ZHANG, Y
    LEE, S
    DRITSCHILO, A
    [J]. SCIENCE, 1995, 268 (5217) : 1619 - 1621
  • [89] Transcription factor NF-kappa B is activated in primary neurons by amyloid beta peptides and in neurons surrounding early plaques from patients with Alzheimer disease
    Kaltschmidt, B
    Uherek, M
    Volk, B
    Baeuerle, PA
    Kaltschmidt, C
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (06) : 2642 - 2647
  • [90] Inhibition of NF-κB potentiates amyloid β-mediated neuronal apoptosis
    Kaltschmidt, B
    Uherek, M
    Wellmann, H
    Volk, B
    Kaltschmidt, C
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (16) : 9409 - 9414