Bacterial penetration across the blood-brain barrier during the development of neonatal meningitis

被引:108
作者
Huang, SH [1 ]
Stins, MF
Kim, KS
机构
[1] Childrens Hosp Los Angeles, Div Infect Dis, Los Angeles, CA 90027 USA
[2] Univ So Calif, Los Angeles, CA 90027 USA
关键词
blood-brain barrier; meningitic bacteria; meningitis; transcytosis; receptors; IbeA; IbeB; YijP; PAF; OmpA;
D O I
10.1016/S1286-4579(00)01277-6
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Bacterial pathogens may breach the blood-brain barrier (BBB) and invade the central nervous system through paracellular and/or transcellular mechanisms. Transcellular penetration, e.g., transcytosis across the BBB has been demonstrated for Escherichia coli K1, group B streptococcus, Listeria monocytogenes, Citrobacter freundii and Streptococcus pneumonia strains. Genes contributing to invasion of brain microvascular endothelial cells include E. coli K1 genes ompA, ibeA, ibeB, and yijP. Understanding the mechanisms of bacterial penetration across the BBB may help develop novel approaches to preventing bacterial meningitis. (C) 2000 Editions scientifiques et medicales Elsevier SAS.
引用
收藏
页码:1237 / 1244
页数:8
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