The riddle of MAP kinase signaling specificity

被引：236

作者：

Madhani, HD ^{[1
]}

Fink, GR ^{[1
]}

机构：

[1] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

来源：

TRENDS IN GENETICS | 1998年 / 14卷 / 04期

关键词：

D O I：

10.1016/S0168-9525(98)01425-5

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Cells encounter an enormous variety of signals hi their environments and must respond to each stimulus appropriately with changes in their genetic programs. Many of these external signals are transduced by a highly conserved eukaryotic signaling mechanism, the mitogen-activated protein kinase (MAPK) cascade. How are the myriad of inputs transduced accurately so that each evokes a specific response? One mechanism would be to have a distinct MAPK cascade for each signal; however, the situation appears to be more complicated.

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页码：151 / 155

页数：5

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