Nitrous oxide (N2O) is a powerful greenhouse gas. As the UK government is committed to reducing greenhouse gas emissions, it is important to know not only how much of these gases are released but also where and when. Targeted measurements of emissions in relation to crop growth cycles, soil wetness and fertiliser applications were used to derive annual emission rates for specific combinations of soil type, land management and fertiliser practices. These annual emission rates were then spatially scaled to derive regional figures through the development of a Geographic Information System (GIS) based model framework. Digital soil and land use maps at a scale of 1: 25 000 for two test areas of approximately 200 000 ha each ( Lothians and the Ayrshire Basin) were overlain with a climate map within the GIS, deriving unique combinations of soil wetness and land use. The calculated annual emission rates (kg N ha(-1) yr(-1)) were then applied to these and multiplied by the total area of each soil/land use type to derive annual emission losses for each area. The annual emission of nitrous oxide from the Lothians was determined as approximately 381 000 kg N yr(-1), while the emissions from the Ayrshire Basin were predicted to be 794 000 kg N yr(-1). This indicates the increased emissions associated with both the wetter soils of Ayrshire and the greater extent of grazed pasture systems in this area. Due to the detailed scale of the input data, localised areas with large emissions were identified. Abatement strategies would be concentrated on areas of high emissions that include a change to crops with lower emission potential, reducing fertiliser and manure inputs, reducing grazing intensity and improving soil drainage.