Differential dynamics of CD4+ and CD8+ T-lymphocyte proliferation and activation in acute simian immunodeficiency virus infection

被引:59
作者
Kaur, A
Hale, CL
Ramanujan, S
Jain, RK
Johnson, RP
机构
[1] Harvard Univ, New England Reg Primate Res Ctr, Sch Med, Div Immunol, Southborough, MA 01772 USA
[2] Massachusetts Gen Hosp, Dept Radiat Oncol, Charlestown, MA 02129 USA
[3] Massachusetts Gen Hosp, Infect Dis Unit, Charlestown, MA 02129 USA
[4] Massachusetts Gen Hosp, Partners AIDS Res Ctr, Charlestown, MA 02129 USA
关键词
D O I
10.1128/JVI.74.18.8413-8424.2000
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Although lymphocyte turnover in chronic human immunodeficiency virus and simian immunodeficiency virus (SN) infection has been extensively studied, there is little information on turnover in acute infection. We carried out a prospective kinetic analysis of lymphocyte proliferation in 13 rhesus macaques inoculated with pathogenic SN. A short-lived dramatic increase in circulating Ki-67(+) lymphocytes observed at 1 to 4 weeks was temporally related to the onset of SIV replication. A 5- to 10-fold increase in Ki-67(+) CD8(+) T lymphocytes and a 2- to 3-fold increase in Ki-67(+) CD3(-) CD8(+) natural killer cells accounted for >85% of proliferating lymphocytes at peak proliferation. In contrast, there was little change in the percentage of Ki-67(+) CD4(+) T lymphocytes during acute infection, although transient increases in Ki-67(-) and Ki-67(+) CD4(+) T lymphocytes expressing CD69, Fas, and HLA-DR were observed, A two- to fourfold decline in CD4(+) T lymphocytes expressing CD25 and CD69 was seen later in SIV infection, The majority of Ki-67(+) CD8(+) T lymphocytes were phenotypically CD45RA(-) CD49d(hi) Fas(hi) CD25(-) CD69(-) CD28(-) HLA-DR- and persisted at levels twofold above baseline 6 months after SIV infection. Increased CD8(+) T-lymphocyte proliferation was associated with cell expansion, paralleled the onset of SIV-specific cytotoxic T-lymphocyte activity, and had an oligoclonal component. Thus, divergent patterns of proliferation and activation are exhibited by CD4(+) and CD8(+) T lymphocytes in early SIV infection and may determine how these cells are differentially affected in AIDS.
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页码:8413 / 8424
页数:12
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