Evidence for oxidative stress in the frontal cortex in patients with recurrent depressive disorder - a postmortem study

被引:166
作者
Michel, Tanja Maria
Frangou, Sophia
Thiemeyer, Dorothea
Camara, Sibylle
Jecel, Julia
Nara, Keinosuke
Brunklaus, Andreas
Zoechling, Robert
Riederer, Peter
机构
[1] Inst Psychiat, Sect Neurobiol Psychosis, London SE5 8AF, England
[2] Univ Hosp Wurzburg, Dept Psychiat & Psychotherapy, D-97080 Wurzburg, Germany
[3] Showa Univ, Sch Med, Dept Pharmacol, Tokyo 1428555, Japan
[4] Guys & St Thomas Hosp, Dept Paediat, London SE1 7EP, England
[5] Hosp Mostviertel, Dept Psychiat, A-3362 Mauer, Austria
关键词
superoxide dismutase; free radicals; brain; antioxidants; mood disorder; depression; hippocampus;
D O I
10.1016/j.psychres.2006.04.013
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Prefrontal cortical (PFC) and hippocampal (HI) volume reductions have been consistently found in patients with recurrent depressive disorder (DD). Here we examine the possibility that oxidative stress, widely implicated in neuronal cell damage, may contribute to these brain structural changes. We compared manganese (Mn) and copper/zinc (Cu/Zn) superoxide dismutase (SOD) coenzyme concentrations in postmortem PFC and hippocampal brain tissue from 7 patients with DD and 7 neuropsychiatrically healthy controls using sandwich-type enzyme-linked immunosorbent assay (ELISA) technique. The concentration of Cu/Zn-SOD was significantly increased in the PFC but not in the hippocampus of patients. There was no significant change in Mn-SOD enzyme concentration in either region. Our findings contribute to the growing body of evidence implicating oxidative stress in the pathophysiology of depressive disorder. (C) 2006 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:145 / 150
页数:6
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