Folate-Receptor-Targeted Delivery of Doxorubicin Using Polyethylene Glycol-Functionalized Gold Nanoparticles

被引：70

作者：

Asadishad, Bahareh ^{[1
]}

Vossoughi, Manouchehr ^{[1
,2
]}

Alemzadeh, Iran ^{[1
,3
]}

机构：

[1] Sharif Univ Technol, Dept Chem & Petr Engn, Tehran, Iran

[2] Sharif Univ Technol, Inst Neurosci, Tehran, Iran

[3] Sharif Univ Technol, Biochem & Bioenvironm Res Ctr, Tehran, Iran

来源：

INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH | 2010年 / 49卷 / 04期

关键词：

DRUG-DELIVERY; MAGNETITE NANOPARTICLES; CANCER; RELEASE; CELLS; CONJUGATION; MICELLES; THERAPY; POLYMER; LYSINE;

D O I：

10.1021/ie9011479

中图分类号：

TQ [化学工业];

学科分类号：

081705 [工业催化];

摘要：

Doxorubicin-loaded nanocarriers were produced employing folate-modified polyethylene glycol (PEG)-functionalized gold nanoparticles for targeted delivery to positive folate-receptor cancer cells. Doxorubicin and folate were, respectively, conjugated to activated-folate and activated-PEG. The conjugates formed doxorubicin nanocarrier with an average size of 12 nm in diameter. The drug release response of functionalized gold nanoparticles was characterized by an initial rapid drug release followed by a controlled release. The doxorubicin nanocarriers showed higher cytotoxic effect on folate-receptor-positive cells (KB cells) than folate-receptor-negative cells (A549 cells). Cell viability in healthy cells (HFF cells) in drug-loaded nanoparticles was higher compared to free doxorubicin. These nanocarriers might offer a cancer therapy with high targeting efficiency and lower side effects.

引用

页码：1958 / 1963

页数：6

共 38 条

[1]

Bioconjugation of interferon-alpha molecules to lysine-capped gold nanoparticles for further drug delivery applications [J].

Aghdam, Atefeh Ghorbani ;

Vossoughi, Manoucher ;

Almzadeh, Iran ;

Zeinali, Majid .

JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY, 2008, 29 (08) :1062-1065

[2]

The synthesis of core-shell iron@gold nanoparticles and their characterization [J].

Ban, ZH ;

Barnakov, YA ;

Golub, VO ;

O'Connor, CJ .

JOURNAL OF MATERIALS CHEMISTRY, 2005, 15 (43) :4660-4662

[3]

Electrochemical release from gold-thiolate electrodes for controlled insertion of ion channels into bilayer membranes [J].

Buchmann, MB ;

Fyles, TM ;

Sutherland, T .

BIOORGANIC & MEDICINAL CHEMISTRY, 2004, 12 (06) :1315-1324

[4]

Glioma selectivity of magnetically targeted nanoparticles: A role of abnormal tumor hydrodynamics [J].

Chertok, Beata ;

David, Allan E. ;

Huang, Yongzhuo ;

Yang, Victor C. .

JOURNAL OF CONTROLLED RELEASE, 2007, 122 (03) :315-323

[5]

Synthesis and grafting of thioctic acid-PEG-folate conjugates onto Au nanoparticles for selective targeting of folate receptor-positive tumor cells [J].

Dixit, Vivechana ;

Van den Bossche, Jeroen ;

Sherman, Debra M. ;

Thompson, David H. ;

Andres, Ronald P. .

BIOCONJUGATE CHEMISTRY, 2006, 17 (03) :603-609

[6]

Nanopartide-aptamer bioconjugates: A new approach for targeting prostate cancer cells [J].

Farokhzad, OC ;

Jon, SY ;

Khademhosseini, A ;

Tran, TNT ;

LaVan, DA ;

Langer, R .

CANCER RESEARCH, 2004, 64 (21) :7668-7672

[7]

GIULIO F, 2005, P 2005 NSTI NAN C TR, V1

[8]

Targeted nanoparticles for cancer therapy [J].

Gu, Frank X. ;

Karnik, Rohit ;

Wang, Andrew Z. ;

Alexis, Frank ;

Levy-Nissenbaum, Etgar ;

Hong, Seungpyo ;

Langer, Robert S. ;

Farokhzad, Omid C. .

NANO TODAY, 2007, 2 (03) :14-21

[9]

HAN G, 2007, J NANOBIOTECHNOL, V3, P40

[10]

HARJANTO T, 2006, GOLD NANOPARTICLE AS

← 1 2 3 4 →