Two ellagitannins from the leaves of Terminalia triflora with inhibitory activity on HIV-1 reverse transcriptase

被引：31

作者：

Martino, V

Morales, J

Martínez-Irujo, JJ

Font, M

Monge, A

Coussio, J

机构：

[1] Univ Buenos Aires, Fac Farm & Bioquim, CONICET, IQUIMEFA,Catedra Farmacognosia, RA-1113 Buenos Aires, DF, Argentina

[2] Univ Buenos Aires, Dept Bioquim, RA-1113 Buenos Aires, DF, Argentina

[3] Univ Navarra, Dept Quim Organ & Farmaceut, Unidad Modelizac Mol, E-31080 Pamplona, Spain

[4] Univ Navarra, Ctr Invest & Farmacobiol Aplicada, E-31080 Pamplona, Spain

来源：

PHYTOTHERAPY RESEARCH | 2004年 / 18卷 / 08期

关键词：

Terminalia triflora-1; combretaceae; punicalim; 2-O-galloyl punicalin; HIV-1-RT inhibition;

D O I：

10.1002/ptr.1504

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The bioassay- guided fractionation of the aqueous extract of Terminalia triflora leaves afforded punicalin and 2-O-galloylpunicalin, isolated for the first time from this species. These compounds showed inhibitory activity on HIV-1 reverse transcriptase in a dose dependant manner. Punicalin showed an IC50 of 0.11 mug/ml (0.14 muM) and 2-O-galloylpunicalin an IC50 of 0.10 mug/ml (0.11 muM). Copyright (C) 2004 John Wiley Sons, Ltd.

引用

页码：667 / 669

页数：3

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