Facile synthesis of 2-alkyl substituted carbapenems via palladium-catalyzed cross-coupling reaction

被引：10

作者：

Narukawa, Y

Nishi, K

Onoue, H

机构：

[1] Shionogi Research Laboratories, Shionogi and Co., Ltd., Osaka 553, Fukushima-ku

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 15期

关键词：

D O I：

10.1016/0040-4039(96)00377-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A direct synthesis of highly functionalized 2-alkylcarbapenems via a palladium-catalyzed cross-coupling reaction of alkylboranes with carbapenem-2-yl triflates is described, An advantage of this procedure is the introduction of C-2 alkyl side chain at the later stage of the synthesis, thus allowing the syntheses of a wide variety of functionalized 2-alkylcarbapenems more accessible. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：2589 / 2592

页数：4

共 15 条

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